SOLENO THERAPEUTICS INC
SLNO
Transaktioner
927
Köp
349
Sälj
578
Nettoinsynsflöde
-725.9 mn USD
Köpvärde minus säljvärde
Rapportanalys
Senast rapporterade siffror, automatiskt granskadeLäser senaste rapporten…
Aktiekurs och insynstransaktioner
Ingen prisdata ännuIngen prisserie har matchats mot detta bolag ännu.
Avkastning efter transaktion
Median-% efter transaktionsdatumKursserien för detta bolag rör sig i tick som är stora i förhållande till aktiekursen, så procentuell avkastning skulle domineras av avrundningsbrus snarare än av verkliga kursrörelser. Avkastningsstatistik visas därför inte.
Signalkorrelation
Månatligt nettoinsynsflöde vs avkastning–
Pearsonkorrelation mellan den signerade logaritmen av månatligt nettoinsynsköp och den månadens aktiekursavkastning, över 0 månader med aktivitet. Värden nära noll innebär att insynsflödet inte gav någon timinginformation för detta bolag.
Alla rapporterade transaktioner
927 rader| Datum | Person | Position | Typ | Volym | Pris | Värde |
|---|---|---|---|---|---|---|
| 2026-05-18 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 584 k | – | – |
| 2026-05-18 | Bir Dawn Carter | Director | Sell | 17 k | – | – |
| 2026-05-18 | Fulk Jennifer | CHIEF FINANCIAL OFFICER | Sell | 39 k | – | – |
| 2026-05-18 | Hahn Mark W | Director | Sell | 10 k | – | – |
| 2026-05-18 | Hirano Patricia C | SEE REMARKS | Sell | 23 k | – | – |
| 2026-05-18 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 40 k | – | – |
| 2026-05-18 | Joshi Manher | Chief Development Officer | Sell | 20 k | – | – |
| 2026-05-18 | Manning Meredith | Chief Commercial Officer | Sell | 65 k | – | – |
| 2026-05-18 | Norrett Kevin | Chief Business Officer | Sell | 18 k | – | – |
| 2026-05-18 | Pauls Matthew | Director | Sell | 10 k | – | – |
| 2026-05-18 | Hahn Mark W | Director | Sell | 10 k | – | – |
| 2026-05-18 | Pauls Matthew | Director | Sell | 10 k | – | – |
| 2026-05-18 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 584 k | – | – |
| 2026-05-18 | Yen Kristen | SEE REMARKS | Sell | 38 k | – | – |
| 2026-05-18 | Bir Dawn Carter | Director | Sell | 17 k | – | – |
| 2026-05-18 | Manning Meredith | Chief Commercial Officer | Sell | 65 k | – | – |
| 2026-05-18 | Volck Birgitte | Director | Sell | 18 k | – | – |
| 2026-05-18 | Sinclair Andrew | Director | Sell | 10 k | – | – |
| 2026-05-18 | Hirano Patricia C | SEE REMARKS | Sell | 23 k | – | – |
| 2026-05-18 | Norrett Kevin | Chief Business Officer | Sell | 18 k | – | – |
| 2026-05-18 | Fulk Jennifer | CHIEF FINANCIAL OFFICER | Sell | 39 k | – | – |
| 2026-05-18 | Joshi Manher | Chief Development Officer | Sell | 20 k | – | – |
| 2026-05-18 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 40 k | – | – |
| 2026-05-18 | Sinclair Andrew | Director | Sell | 10 k | – | – |
| 2026-05-18 | Volck Birgitte | Director | Sell | 18 k | – | – |
| 2026-05-18 | Yen Kristen | SEE REMARKS | Sell | 38 k | – | – |
| 2026-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 4 k | 30,04 | 128 k USD |
| 2026-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 2 k | 31,04 | 57 k USD |
| 2026-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 488 | 31,72 | 15 k USD |
| 2026-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 5 k | 30,04 | 146 k USD |
| 2026-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 2 k | 31,04 | 65 k USD |
| 2026-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 558 | 31,72 | 18 k USD |
| 2026-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 5 k | 30,04 | 146 k USD |
| 2026-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 2 k | 31,04 | 65 k USD |
| 2026-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 558 | 31,72 | 18 k USD |
| 2026-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 4 k | 30,04 | 128 k USD |
| 2026-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 2 k | 31,04 | 57 k USD |
| 2026-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 488 | 31,72 | 15 k USD |
| 2026-03-02 | Fulk Jennifer | CHIEF FINANCIAL OFFICER | Buy | 39 k | 0,00 | 0 USD |
| 2026-03-02 | Fulk Jennifer | CHIEF FINANCIAL OFFICER | Buy | 39 k | 0,00 | 0 USD |
| 2026-01-21 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 114 k | 0,00 | 0 USD |
| 2026-01-21 | Hirano Patricia C | SEE REMARKS | Buy | 10 k | 0,00 | 0 USD |
| 2026-01-21 | Huang Michael F. | Sr. VP of Clinical Development | Buy | 10 k | 0,00 | 0 USD |
| 2026-01-21 | Joshi Manher | Chief Development Officer | Buy | 4 k | 0,00 | 0 USD |
| 2026-01-21 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 29 k | 0,00 | 0 USD |
| 2026-01-21 | Manning Meredith | Chief Commercial Officer | Buy | 29 k | 0,00 | 0 USD |
| 2026-01-21 | Norrett Kevin | Chief Business Officer | Buy | 4 k | 0,00 | 0 USD |
| 2026-01-21 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 29 k | 0,00 | 0 USD |
| 2026-01-21 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 114 k | 0,00 | 0 USD |
| 2026-01-21 | Yen Kristen | SEE REMARKS | Buy | 10 k | 0,00 | 0 USD |
| 2026-01-21 | Manning Meredith | Chief Commercial Officer | Buy | 29 k | 0,00 | 0 USD |
| 2026-01-21 | Hirano Patricia C | SEE REMARKS | Buy | 10 k | 0,00 | 0 USD |
| 2026-01-21 | Norrett Kevin | Chief Business Officer | Buy | 4 k | 0,00 | 0 USD |
| 2026-01-21 | Joshi Manher | Chief Development Officer | Buy | 4 k | 0,00 | 0 USD |
| 2026-01-21 | Huang Michael F. | Sr. VP of Clinical Development | Buy | 10 k | 0,00 | 0 USD |
| 2026-01-21 | Yen Kristen | SEE REMARKS | Buy | 10 k | 0,00 | 0 USD |
| 2025-12-15 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 8 k | 49,95 | 381 k USD |
| 2025-12-15 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 100 k | 0,00 | 0 USD |
| 2025-12-15 | Hirano Patricia C | SEE REMARKS | Sell | 904 | 49,95 | 45 k USD |
| 2025-12-15 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 812 | 49,95 | 41 k USD |
| 2025-12-15 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 2 k | 49,95 | 101 k USD |
| 2025-12-15 | Manning Meredith | Chief Commercial Officer | Sell | 2 k | 49,95 | 96 k USD |
| 2025-12-15 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 2 k | 49,95 | 101 k USD |
| 2025-12-15 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 8 k | 49,95 | 381 k USD |
| 2025-12-15 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 100 k | 0,00 | 0 USD |
| 2025-12-15 | Yen Kristen | SEE REMARKS | Sell | 904 | 49,95 | 45 k USD |
| 2025-12-15 | Manning Meredith | Chief Commercial Officer | Sell | 2 k | 49,95 | 96 k USD |
| 2025-12-15 | Hirano Patricia C | SEE REMARKS | Sell | 904 | 49,95 | 45 k USD |
| 2025-12-15 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 812 | 49,95 | 41 k USD |
| 2025-12-15 | Yen Kristen | SEE REMARKS | Sell | 904 | 49,95 | 45 k USD |
| 2025-11-17 | Norrett Kevin | Chief Business Officer | Buy | 14 k | 0,00 | 0 USD |
| 2025-11-17 | Norrett Kevin | Chief Business Officer | Buy | 14 k | 0,00 | 0 USD |
| 2025-11-10 | Joshi Manher | Chief Development Officer | Buy | 16 k | 0,00 | 0 USD |
| 2025-11-10 | Joshi Manher | Chief Development Officer | Buy | 16 k | 0,00 | 0 USD |
| 2025-10-13 | Hahn Mark W | Director | Buy | 10 k | 0,00 | 0 USD |
| 2025-10-13 | Hahn Mark W | Director | Buy | 10 k | 0,00 | 0 USD |
| 2025-07-01 | Hirano Patricia C | SEE REMARKS | Sell | 4 k | 82,76 | 317 k USD |
| 2025-07-01 | Hirano Patricia C | SEE REMARKS | Sell | 4 k | 82,76 | 317 k USD |
| 2025-06-24 | Hirano Patricia C | SEE REMARKS | Buy | 266 | 44,25 | 12 k USD |
| 2025-06-24 | Hirano Patricia C | SEE REMARKS | Sell | 266 | 84,25 | 22 k USD |
| 2025-06-24 | Hirano Patricia C | SEE REMARKS | Buy | 266 | 44,25 | 12 k USD |
| 2025-06-24 | Hirano Patricia C | SEE REMARKS | Sell | 266 | 84,25 | 22 k USD |
| 2025-06-05 | Bir Dawn Carter | Director | Buy | 4 k | 0,00 | 0 USD |
| 2025-06-05 | Harris William G | Director | Buy | 4 k | 0,00 | 0 USD |
| 2025-06-05 | Pauls Matthew | Director | Buy | 4 k | 0,00 | 0 USD |
| 2025-06-05 | Bir Dawn Carter | Director | Buy | 4 k | 0,00 | 0 USD |
| 2025-06-05 | Harris William G | Director | Buy | 4 k | 0,00 | 0 USD |
| 2025-06-05 | Pauls Matthew | Director | Buy | 4 k | 0,00 | 0 USD |
| 2025-06-05 | Sinclair Andrew | Director | Buy | 4 k | 0,00 | 0 USD |
| 2025-06-05 | Volck Birgitte | Director | Buy | 4 k | 0,00 | 0 USD |
| 2025-06-05 | Sinclair Andrew | Director | Buy | 4 k | 0,00 | 0 USD |
| 2025-06-05 | Volck Birgitte | Director | Buy | 4 k | 0,00 | 0 USD |
| 2025-04-01 | Hirano Patricia C | SEE REMARKS | Sell | 4 k | 70,11 | 265 k USD |
| 2025-04-01 | Hirano Patricia C | SEE REMARKS | Sell | 4 k | 70,11 | 265 k USD |
| 2025-03-28 | Hirano Patricia C | SEE REMARKS | Buy | 3 k | 33,60 | 90 k USD |
| 2025-03-28 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 67,46 | 229 k USD |
| 2025-03-28 | Hirano Patricia C | SEE REMARKS | Sell | 12 k | 68,92 | 849 k USD |
| 2025-03-28 | Hirano Patricia C | SEE REMARKS | Sell | 9 k | 69,52 | 643 k USD |
| 2025-03-28 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 73,60 | 198 k USD |
| 2025-03-28 | Pauls Matthew | Director | Buy | 6 k | 4,60 | 27 k USD |
| 2025-03-28 | Pauls Matthew | Director | Sell | 6 k | 71,55 | 425 k USD |
| 2025-03-28 | Hirano Patricia C | SEE REMARKS | Buy | 3 k | 33,60 | 90 k USD |
| 2025-03-28 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 67,46 | 229 k USD |
| 2025-03-28 | Hirano Patricia C | SEE REMARKS | Sell | 12 k | 68,92 | 849 k USD |
| 2025-03-28 | Hirano Patricia C | SEE REMARKS | Sell | 9 k | 69,52 | 643 k USD |
| 2025-03-28 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 73,60 | 198 k USD |
| 2025-03-28 | Pauls Matthew | Director | Sell | 6 k | 71,55 | 425 k USD |
| 2025-03-28 | Pauls Matthew | Director | Buy | 6 k | 4,60 | 27 k USD |
| 2025-03-28 | Vivo Opportunity, LLC | 10% owner | Sell | 334 k | 70,60 | 23.5 mn USD |
| 2025-03-28 | Vivo Opportunity, LLC | 10% owner | Sell | 334 k | 70,60 | 23.5 mn USD |
| 2025-03-28 | Vivo Opportunity, LLC | 10% owner | Sell | 334 k | 70,60 | 23.5 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 14 k | 65,97 | 936 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 23 k | 66,79 | 1.5 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 42 k | 67,70 | 2.8 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 55 k | 68,79 | 3.8 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 32 k | 69,84 | 2.2 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 3 k | 70,73 | 233 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 5 k | 71,74 | 343 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 732 | 72,64 | 53 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 27 k | 24,00 | 639 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 17 k | 25,05 | 417 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 105 k | 33,60 | 3.5 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 32 k | 5,10 | 164 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 62 k | 2,41 | 150 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 281 k | 5,25 | 1.5 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 106 k | 65,81 | 7.0 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 210 k | 66,33 | 13.9 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 8 k | 67,37 | 567 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 199 k | 69,30 | 13.8 mn USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 1 k | 65,97 | 94 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 2 k | 66,79 | 154 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 4 k | 67,70 | 284 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 6 k | 68,79 | 380 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 69,84 | 223 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 329 | 70,73 | 23 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 478 | 71,74 | 34 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 73 | 72,64 | 5 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 6 k | 24,00 | 144 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 4 k | 25,05 | 110 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 5 k | 5,10 | 25 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 13 k | 2,60 | 35 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 8 k | 2,41 | 20 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 35 k | 5,25 | 185 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 46 k | 66,39 | 3.1 mn USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 25 k | 67,47 | 1.7 mn USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 25 k | 70,18 | 1.8 mn USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 15 k | 72,50 | 1.1 mn USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 371 | 65,97 | 24 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 604 | 66,79 | 40 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 1 k | 67,70 | 74 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 1 k | 68,79 | 99 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 836 | 69,84 | 58 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 86 | 70,73 | 6 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 125 | 71,74 | 9 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 19 | 72,64 | 1 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Buy | 10 k | 21,93 | 219 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 10 k | 70,03 | 700 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 2 k | 65,97 | 110 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 3 k | 66,79 | 181 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 5 k | 67,70 | 334 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 6 k | 68,79 | 447 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 4 k | 69,84 | 263 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 387 | 70,73 | 27 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 563 | 71,74 | 40 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 86 | 72,64 | 6 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 20 k | 30,75 | 615 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 10 k | 5,10 | 51 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 5 k | 2,60 | 13 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 15 k | 2,41 | 36 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 20 k | 5,25 | 105 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 26 k | 69,07 | 1.8 mn USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 36 k | 70,03 | 2.5 mn USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 8 k | 70,80 | 569 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 668 | 65,97 | 44 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 1 k | 66,79 | 73 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 2 k | 67,70 | 134 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 3 k | 68,79 | 179 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 2 k | 69,84 | 105 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 155 | 70,73 | 11 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 225 | 71,74 | 16 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 34 | 72,64 | 2 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Buy | 37 k | 46,31 | 1.7 mn USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 37 k | 67,04 | 2.5 mn USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 1 k | 65,97 | 94 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 14 k | 65,97 | 936 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 23 k | 66,79 | 1.5 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 42 k | 67,70 | 2.8 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 55 k | 68,79 | 3.8 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 32 k | 69,84 | 2.2 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 3 k | 70,73 | 233 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 5 k | 71,74 | 343 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 732 | 72,64 | 53 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 27 k | 24,00 | 639 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 17 k | 25,05 | 417 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 105 k | 33,60 | 3.5 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 32 k | 5,10 | 164 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 62 k | 2,41 | 150 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 281 k | 5,25 | 1.5 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 106 k | 65,81 | 7.0 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 210 k | 66,33 | 13.9 mn USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 8 k | 67,37 | 567 k USD |
| 2025-03-27 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 199 k | 69,30 | 13.8 mn USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 2 k | 66,79 | 154 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 4 k | 67,70 | 284 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 6 k | 68,79 | 380 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 69,84 | 223 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 329 | 70,73 | 23 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 478 | 71,74 | 34 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 73 | 72,64 | 5 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 6 k | 24,00 | 144 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 4 k | 25,05 | 110 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 5 k | 5,10 | 25 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 13 k | 2,60 | 35 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 8 k | 2,41 | 20 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Buy | 35 k | 5,25 | 185 k USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 46 k | 66,39 | 3.1 mn USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 25 k | 67,47 | 1.7 mn USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 25 k | 70,18 | 1.8 mn USD |
| 2025-03-27 | Hirano Patricia C | SEE REMARKS | Sell | 15 k | 72,50 | 1.1 mn USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 371 | 65,97 | 24 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 604 | 66,79 | 40 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 1 k | 67,70 | 74 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 1 k | 68,79 | 99 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 836 | 69,84 | 58 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 86 | 70,73 | 6 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 125 | 71,74 | 9 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 19 | 72,64 | 1 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Buy | 10 k | 21,93 | 219 k USD |
| 2025-03-27 | Huang Michael F. | Sr. VP of Clinical Development | Sell | 10 k | 70,03 | 700 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 2 k | 65,97 | 110 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 3 k | 66,79 | 181 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 5 k | 67,70 | 334 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 6 k | 68,79 | 447 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 4 k | 69,84 | 263 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 387 | 70,73 | 27 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 563 | 71,74 | 40 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 86 | 72,64 | 6 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 20 k | 30,75 | 615 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 10 k | 5,10 | 51 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 5 k | 2,60 | 13 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 15 k | 2,41 | 36 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 20 k | 5,25 | 105 k USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 26 k | 69,07 | 1.8 mn USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 36 k | 70,03 | 2.5 mn USD |
| 2025-03-27 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 8 k | 70,80 | 569 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 668 | 65,97 | 44 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 1 k | 66,79 | 73 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 2 k | 67,70 | 134 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 3 k | 68,79 | 179 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 2 k | 69,84 | 105 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 155 | 70,73 | 11 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 225 | 71,74 | 16 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 34 | 72,64 | 2 k USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Buy | 37 k | 46,31 | 1.7 mn USD |
| 2025-03-27 | Manning Meredith | Chief Commercial Officer | Sell | 37 k | 67,04 | 2.5 mn USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 2 k | 65,97 | 117 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 3 k | 66,79 | 192 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 5 k | 67,70 | 355 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 7 k | 68,79 | 474 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 4 k | 69,84 | 279 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 411 | 70,73 | 29 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 597 | 71,74 | 43 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 91 | 72,64 | 7 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Buy | 5 k | 5,10 | 25 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Buy | 4 k | 2,41 | 9 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Buy | 32 k | 5,25 | 168 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 50 k | 66,00 | 3.3 mn USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 23 k | 66,95 | 1.6 mn USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 2 k | 65,97 | 117 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 3 k | 66,79 | 192 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 5 k | 67,70 | 355 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 7 k | 68,79 | 474 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 4 k | 69,84 | 279 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 411 | 70,73 | 29 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 597 | 71,74 | 43 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 91 | 72,64 | 7 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Buy | 5 k | 5,10 | 25 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Buy | 4 k | 2,41 | 9 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Buy | 32 k | 5,25 | 168 k USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 50 k | 66,00 | 3.3 mn USD |
| 2025-03-27 | Yen Kristen | SEE REMARKS | Sell | 23 k | 66,95 | 1.6 mn USD |
| 2025-03-27 | Vivo Opportunity, LLC | 10% owner | Sell | 1.1 mn | 67,80 | 74.6 mn USD |
| 2025-03-27 | Vivo Opportunity, LLC | 10% owner | Sell | 1.1 mn | 67,80 | 74.6 mn USD |
| 2025-03-27 | Vivo Opportunity, LLC | 10% owner | Sell | 1.1 mn | 67,80 | 74.6 mn USD |
| 2025-03-26 | Vivo Opportunity, LLC | 10% owner | Sell | 400 k | 65,80 | 26.3 mn USD |
| 2025-03-26 | Vivo Opportunity, LLC | 10% owner | Sell | 400 k | 65,80 | 26.3 mn USD |
| 2025-03-26 | Vivo Opportunity, LLC | 10% owner | Sell | 400 k | 65,80 | 26.3 mn USD |
| 2025-01-21 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 54 k | 0,00 | 0 USD |
| 2025-01-21 | Hirano Patricia C | SEE REMARKS | Buy | 6 k | 0,00 | 0 USD |
| 2025-01-21 | Huang Michael F. | Sr. VP of Clinical Development | Buy | 6 k | 0,00 | 0 USD |
| 2025-01-21 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 15 k | 0,00 | 0 USD |
| 2025-01-21 | Manning Meredith | Chief Commercial Officer | Buy | 14 k | 0,00 | 0 USD |
| 2025-01-21 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 54 k | 0,00 | 0 USD |
| 2025-01-21 | Hirano Patricia C | SEE REMARKS | Buy | 6 k | 0,00 | 0 USD |
| 2025-01-21 | Huang Michael F. | Sr. VP of Clinical Development | Buy | 6 k | 0,00 | 0 USD |
| 2025-01-21 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 15 k | 0,00 | 0 USD |
| 2025-01-21 | Manning Meredith | Chief Commercial Officer | Buy | 14 k | 0,00 | 0 USD |
| 2025-01-21 | Yen Kristen | SEE REMARKS | Buy | 6 k | 0,00 | 0 USD |
| 2025-01-21 | Yen Kristen | SEE REMARKS | Buy | 6 k | 0,00 | 0 USD |
| 2025-01-03 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 10 k | 46,18 | 469 k USD |
| 2025-01-03 | Hirano Patricia C | SEE REMARKS | Sell | 1 k | 46,18 | 67 k USD |
| 2025-01-03 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 4 k | 46,18 | 175 k USD |
| 2025-01-03 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 10 k | 46,18 | 469 k USD |
| 2025-01-03 | Hirano Patricia C | SEE REMARKS | Sell | 1 k | 46,18 | 67 k USD |
| 2025-01-03 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 4 k | 46,18 | 175 k USD |
| 2025-01-03 | Yen Kristen | SEE REMARKS | Sell | 2 k | 46,18 | 108 k USD |
| 2025-01-03 | Yen Kristen | SEE REMARKS | Sell | 2 k | 46,18 | 108 k USD |
| 2025-01-02 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 10 k | 45,37 | 457 k USD |
| 2025-01-02 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 860 | 45,92 | 39 k USD |
| 2025-01-02 | Hirano Patricia C | SEE REMARKS | Sell | 1 k | 45,37 | 66 k USD |
| 2025-01-02 | Hirano Patricia C | SEE REMARKS | Sell | 124 | 45,92 | 6 k USD |
| 2025-01-02 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 4 k | 45,37 | 171 k USD |
| 2025-01-02 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 321 | 45,92 | 15 k USD |
| 2025-01-02 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 10 k | 45,37 | 457 k USD |
| 2025-01-02 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 860 | 45,92 | 39 k USD |
| 2025-01-02 | Hirano Patricia C | SEE REMARKS | Sell | 1 k | 45,37 | 66 k USD |
| 2025-01-02 | Hirano Patricia C | SEE REMARKS | Sell | 124 | 45,92 | 6 k USD |
| 2025-01-02 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 4 k | 45,37 | 171 k USD |
| 2025-01-02 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 321 | 45,92 | 15 k USD |
| 2025-01-02 | Yen Kristen | SEE REMARKS | Sell | 2 k | 45,37 | 105 k USD |
| 2025-01-02 | Yen Kristen | SEE REMARKS | Sell | 198 | 45,92 | 9 k USD |
| 2025-01-02 | Yen Kristen | SEE REMARKS | Sell | 2 k | 45,37 | 105 k USD |
| 2025-01-02 | Yen Kristen | SEE REMARKS | Sell | 198 | 45,92 | 9 k USD |
| 2024-10-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 19 k | 49,34 | 958 k USD |
| 2024-10-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 2 k | 50,25 | 112 k USD |
| 2024-10-01 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 49,34 | 138 k USD |
| 2024-10-01 | Hirano Patricia C | SEE REMARKS | Sell | 319 | 50,25 | 16 k USD |
| 2024-10-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 7 k | 49,34 | 358 k USD |
| 2024-10-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 829 | 50,25 | 42 k USD |
| 2024-10-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 19 k | 49,34 | 958 k USD |
| 2024-10-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 2 k | 50,25 | 112 k USD |
| 2024-10-01 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 49,34 | 138 k USD |
| 2024-10-01 | Hirano Patricia C | SEE REMARKS | Sell | 319 | 50,25 | 16 k USD |
| 2024-10-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 7 k | 49,34 | 358 k USD |
| 2024-10-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 829 | 50,25 | 42 k USD |
| 2024-10-01 | Yen Kristen | SEE REMARKS | Sell | 3 k | 49,34 | 138 k USD |
| 2024-10-01 | Yen Kristen | SEE REMARKS | Sell | 319 | 50,25 | 16 k USD |
| 2024-10-01 | Yen Kristen | SEE REMARKS | Sell | 3 k | 49,34 | 138 k USD |
| 2024-10-01 | Yen Kristen | SEE REMARKS | Sell | 319 | 50,25 | 16 k USD |
| 2024-08-29 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 48 k | 47,16 | 2.2 mn USD |
| 2024-08-29 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 11 k | 47,83 | 519 k USD |
| 2024-08-29 | Hirano Patricia C | SEE REMARKS | Sell | 4 k | 47,16 | 209 k USD |
| 2024-08-29 | Hirano Patricia C | SEE REMARKS | Sell | 1 k | 47,83 | 48 k USD |
| 2024-08-29 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 6 k | 47,16 | 264 k USD |
| 2024-08-29 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 1 k | 47,83 | 61 k USD |
| 2024-08-29 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 48 k | 47,16 | 2.2 mn USD |
| 2024-08-29 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 11 k | 47,83 | 519 k USD |
| 2024-08-29 | Hirano Patricia C | SEE REMARKS | Sell | 4 k | 47,16 | 209 k USD |
| 2024-08-29 | Hirano Patricia C | SEE REMARKS | Sell | 1 k | 47,83 | 48 k USD |
| 2024-08-29 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 6 k | 47,16 | 264 k USD |
| 2024-08-29 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 1 k | 47,83 | 61 k USD |
| 2024-08-29 | Yen Kristen | SEE REMARKS | Sell | 4 k | 47,16 | 209 k USD |
| 2024-08-29 | Yen Kristen | SEE REMARKS | Sell | 1 k | 47,83 | 48 k USD |
| 2024-08-29 | Yen Kristen | SEE REMARKS | Sell | 4 k | 47,16 | 209 k USD |
| 2024-08-29 | Yen Kristen | SEE REMARKS | Sell | 1 k | 47,83 | 48 k USD |
| 2024-08-29 | Vivo Opportunity, LLC | 10% owner | Sell | 100 k | 47,22 | 4.7 mn USD |
| 2024-08-29 | Vivo Opportunity, LLC | 10% owner | Sell | 100 k | 47,22 | 4.7 mn USD |
| 2024-08-29 | Vivo Opportunity, LLC | 10% owner | Sell | 100 k | 47,22 | 4.7 mn USD |
| 2024-08-28 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 30 k | 47,19 | 1.4 mn USD |
| 2024-08-28 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 26 k | 48,03 | 1.3 mn USD |
| 2024-08-28 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 47,19 | 133 k USD |
| 2024-08-28 | Hirano Patricia C | SEE REMARKS | Sell | 2 k | 48,03 | 118 k USD |
| 2024-08-28 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 4 k | 47,19 | 168 k USD |
| 2024-08-28 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 3 k | 48,03 | 149 k USD |
| 2024-08-28 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 30 k | 47,19 | 1.4 mn USD |
| 2024-08-28 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 26 k | 48,03 | 1.3 mn USD |
| 2024-08-28 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 47,19 | 133 k USD |
| 2024-08-28 | Hirano Patricia C | SEE REMARKS | Sell | 2 k | 48,03 | 118 k USD |
| 2024-08-28 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 4 k | 47,19 | 168 k USD |
| 2024-08-28 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 3 k | 48,03 | 149 k USD |
| 2024-08-28 | Yen Kristen | SEE REMARKS | Sell | 3 k | 47,19 | 133 k USD |
| 2024-08-28 | Yen Kristen | SEE REMARKS | Sell | 2 k | 48,03 | 118 k USD |
| 2024-08-28 | Yen Kristen | SEE REMARKS | Sell | 3 k | 47,19 | 133 k USD |
| 2024-08-28 | Yen Kristen | SEE REMARKS | Sell | 2 k | 48,03 | 118 k USD |
| 2024-08-28 | Vivo Opportunity, LLC | 10% owner | Sell | 425 k | 47,35 | 20.1 mn USD |
| 2024-08-28 | Vivo Opportunity, LLC | 10% owner | Sell | 425 k | 47,35 | 20.1 mn USD |
| 2024-08-28 | Vivo Opportunity, LLC | 10% owner | Sell | 425 k | 47,35 | 20.1 mn USD |
| 2024-08-27 | Vivo Opportunity, LLC | 10% owner | Sell | 500 k | 48,73 | 24.4 mn USD |
| 2024-08-27 | Vivo Opportunity, LLC | 10% owner | Sell | 500 k | 48,73 | 24.4 mn USD |
| 2024-08-27 | Vivo Opportunity, LLC | 10% owner | Sell | 500 k | 48,73 | 24.4 mn USD |
| 2024-08-15 | Bir Dawn Carter | Director | Buy | 13 k | 0,00 | 0 USD |
| 2024-08-15 | Bir Dawn Carter | Director | Buy | 13 k | 0,00 | 0 USD |
| 2024-08-06 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 7 k | 43,64 | 296 k USD |
| 2024-08-06 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 23 k | 45,25 | 1.0 mn USD |
| 2024-08-06 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 39 k | 45,89 | 1.8 mn USD |
| 2024-08-06 | Hirano Patricia C | SEE REMARKS | Sell | 587 | 43,64 | 26 k USD |
| 2024-08-06 | Hirano Patricia C | SEE REMARKS | Sell | 2 k | 45,25 | 90 k USD |
| 2024-08-06 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 45,89 | 156 k USD |
| 2024-08-06 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 799 | 43,64 | 35 k USD |
| 2024-08-06 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 3 k | 45,25 | 122 k USD |
| 2024-08-06 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 5 k | 45,89 | 213 k USD |
| 2024-08-06 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 7 k | 43,64 | 296 k USD |
| 2024-08-06 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 23 k | 45,25 | 1.0 mn USD |
| 2024-08-06 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 39 k | 45,89 | 1.8 mn USD |
| 2024-08-06 | Hirano Patricia C | SEE REMARKS | Sell | 587 | 43,64 | 26 k USD |
| 2024-08-06 | Hirano Patricia C | SEE REMARKS | Sell | 2 k | 45,25 | 90 k USD |
| 2024-08-06 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 45,89 | 156 k USD |
| 2024-08-06 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 799 | 43,64 | 35 k USD |
| 2024-08-06 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 3 k | 45,25 | 122 k USD |
| 2024-08-06 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 5 k | 45,89 | 213 k USD |
| 2024-08-06 | Yen Kristen | SEE REMARKS | Sell | 585 | 43,64 | 26 k USD |
| 2024-08-06 | Yen Kristen | SEE REMARKS | Sell | 2 k | 45,25 | 89 k USD |
| 2024-08-06 | Yen Kristen | SEE REMARKS | Sell | 3 k | 45,89 | 156 k USD |
| 2024-08-06 | Yen Kristen | SEE REMARKS | Sell | 585 | 43,64 | 26 k USD |
| 2024-08-06 | Yen Kristen | SEE REMARKS | Sell | 2 k | 45,25 | 89 k USD |
| 2024-08-06 | Yen Kristen | SEE REMARKS | Sell | 3 k | 45,89 | 156 k USD |
| 2024-08-05 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 33 k | 45,48 | 1.5 mn USD |
| 2024-08-05 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 25 k | 46,14 | 1.2 mn USD |
| 2024-08-05 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 45,48 | 129 k USD |
| 2024-08-05 | Hirano Patricia C | SEE REMARKS | Sell | 2 k | 46,14 | 101 k USD |
| 2024-08-05 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 4 k | 45,48 | 175 k USD |
| 2024-08-05 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 3 k | 46,14 | 138 k USD |
| 2024-08-05 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 33 k | 45,48 | 1.5 mn USD |
| 2024-08-05 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 25 k | 46,14 | 1.2 mn USD |
| 2024-08-05 | Hirano Patricia C | SEE REMARKS | Sell | 3 k | 45,48 | 129 k USD |
| 2024-08-05 | Hirano Patricia C | SEE REMARKS | Sell | 2 k | 46,14 | 101 k USD |
| 2024-08-05 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 4 k | 45,48 | 175 k USD |
| 2024-08-05 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 3 k | 46,14 | 138 k USD |
| 2024-08-05 | Yen Kristen | SEE REMARKS | Sell | 3 k | 45,48 | 129 k USD |
| 2024-08-05 | Yen Kristen | SEE REMARKS | Sell | 2 k | 46,14 | 101 k USD |
| 2024-08-05 | Yen Kristen | SEE REMARKS | Sell | 3 k | 45,48 | 129 k USD |
| 2024-08-05 | Yen Kristen | SEE REMARKS | Sell | 2 k | 46,14 | 101 k USD |
| 2024-07-17 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 850 k | 0,00 | 0 USD |
| 2024-07-17 | Hirano Patricia C | SEE REMARKS | Buy | 85 k | 0,00 | 0 USD |
| 2024-07-17 | Huang Michael F. | Sr. VP of Clinical Development | Buy | 35 k | 0,00 | 0 USD |
| 2024-07-17 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 100 k | 0,00 | 0 USD |
| 2024-07-17 | Manning Meredith | Chief Commercial Officer | Buy | 40 k | 0,00 | 0 USD |
| 2024-07-17 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Buy | 850 k | 0,00 | 0 USD |
| 2024-07-17 | Mackaness James H | CHIEF FINANCIAL OFFICER | Buy | 100 k | 0,00 | 0 USD |
| 2024-07-17 | Hirano Patricia C | SEE REMARKS | Buy | 85 k | 0,00 | 0 USD |
| 2024-07-17 | Yen Kristen | SEE REMARKS | Buy | 85 k | 0,00 | 0 USD |
| 2024-07-17 | Huang Michael F. | Sr. VP of Clinical Development | Buy | 35 k | 0,00 | 0 USD |
| 2024-07-17 | Manning Meredith | Chief Commercial Officer | Buy | 40 k | 0,00 | 0 USD |
| 2024-07-17 | Yen Kristen | SEE REMARKS | Buy | 85 k | 0,00 | 0 USD |
| 2024-07-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 4 k | 41,22 | 173 k USD |
| 2024-07-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 15 k | 41,63 | 627 k USD |
| 2024-07-01 | Hirano Patricia C | SEE REMARKS | Sell | 473 | 41,22 | 19 k USD |
| 2024-07-01 | Hirano Patricia C | SEE REMARKS | Sell | 2 k | 41,63 | 71 k USD |
| 2024-07-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 2 k | 41,22 | 65 k USD |
| 2024-07-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 6 k | 41,63 | 234 k USD |
| 2024-07-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 4 k | 41,22 | 173 k USD |
| 2024-07-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 15 k | 41,63 | 627 k USD |
| 2024-07-01 | Hirano Patricia C | SEE REMARKS | Sell | 473 | 41,22 | 19 k USD |
| 2024-07-01 | Hirano Patricia C | SEE REMARKS | Sell | 2 k | 41,63 | 71 k USD |
| 2024-07-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 2 k | 41,22 | 65 k USD |
| 2024-07-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 6 k | 41,63 | 234 k USD |
| 2024-07-01 | Yen Kristen | SEE REMARKS | Sell | 473 | 41,22 | 19 k USD |
| 2024-07-01 | Yen Kristen | SEE REMARKS | Sell | 2 k | 41,63 | 71 k USD |
| 2024-07-01 | Yen Kristen | SEE REMARKS | Sell | 473 | 41,22 | 19 k USD |
| 2024-07-01 | Yen Kristen | SEE REMARKS | Sell | 2 k | 41,63 | 71 k USD |
| 2024-06-06 | Harris William G | Director | Buy | 7 k | 0,00 | 0 USD |
| 2024-06-06 | MARIO ERNEST | Director | Buy | 7 k | 0,00 | 0 USD |
| 2024-06-06 | Pauls Matthew | Director | Buy | 7 k | 0,00 | 0 USD |
| 2024-06-06 | Harris William G | Director | Buy | 7 k | 0,00 | 0 USD |
| 2024-06-06 | MARIO ERNEST | Director | Buy | 7 k | 0,00 | 0 USD |
| 2024-06-06 | Pauls Matthew | Director | Buy | 7 k | 0,00 | 0 USD |
| 2024-06-06 | Sinclair Andrew | Director | Buy | 7 k | 0,00 | 0 USD |
| 2024-06-06 | Volck Birgitte | Director | Buy | 7 k | 0,00 | 0 USD |
| 2024-06-06 | Sinclair Andrew | Director | Buy | 7 k | 0,00 | 0 USD |
| 2024-06-06 | Volck Birgitte | Director | Buy | 7 k | 0,00 | 0 USD |
| 2024-05-21 | MARIO ERNEST | Director | Buy | 62 k | 4,50 | 279 k USD |
| 2024-05-21 | MARIO ERNEST | Director | Buy | 62 k | 4,50 | 279 k USD |
| 2024-04-30 | Vivo Opportunity, LLC | 10% owner | Sell | 351 k | 45,13 | 15.9 mn USD |
| 2024-04-30 | Vivo Opportunity, LLC | 10% owner | Sell | 351 k | 45,13 | 15.9 mn USD |
| 2024-04-30 | Vivo Opportunity, LLC | 10% owner | Sell | 351 k | 45,13 | 15.9 mn USD |
| 2024-04-29 | Vivo Opportunity, LLC | 10% owner | Sell | 750 k | 47,80 | 35.9 mn USD |
| 2024-04-29 | Vivo Opportunity, LLC | 10% owner | Sell | 750 k | 47,80 | 35.9 mn USD |
| 2024-04-29 | Vivo Opportunity, LLC | 10% owner | Sell | 750 k | 47,80 | 35.9 mn USD |
| 2024-04-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 11 k | 41,12 | 468 k USD |
| 2024-04-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 8 k | 41,67 | 317 k USD |
| 2024-04-01 | Hirano Patricia C | SEE REMARKS | Sell | 1 k | 41,12 | 55 k USD |
| 2024-04-01 | Hirano Patricia C | SEE REMARKS | Sell | 888 | 41,67 | 37 k USD |
| 2024-04-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 3 k | 41,12 | 128 k USD |
| 2024-04-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 2 k | 41,67 | 86 k USD |
| 2024-04-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 11 k | 41,12 | 468 k USD |
| 2024-04-01 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 8 k | 41,67 | 317 k USD |
| 2024-04-01 | Hirano Patricia C | SEE REMARKS | Sell | 1 k | 41,12 | 55 k USD |
| 2024-04-01 | Hirano Patricia C | SEE REMARKS | Sell | 888 | 41,67 | 37 k USD |
| 2024-04-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 3 k | 41,12 | 128 k USD |
| 2024-04-01 | Mackaness James H | CHIEF FINANCIAL OFFICER | Sell | 2 k | 41,67 | 86 k USD |
| 2024-04-01 | Yen Kristen | SEE REMARKS | Sell | 1 k | 41,12 | 55 k USD |
| 2024-04-01 | Yen Kristen | SEE REMARKS | Sell | 888 | 41,67 | 37 k USD |
| 2024-04-01 | Yen Kristen | SEE REMARKS | Sell | 1 k | 41,12 | 55 k USD |
| 2024-04-01 | Yen Kristen | SEE REMARKS | Sell | 888 | 41,67 | 37 k USD |
| 2024-01-25 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 3 k | 48,30 | 122 k USD |
| 2024-01-25 | Hirano Patricia C | SEE REMARKS | Sell | 832 | 48,30 | 40 k USD |
| 2024-01-25 | Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | Sell | 3 k | 48,30 | 122 k USD |
| 2024-01-25 | Hirano Patricia C | SEE REMARKS | Sell | 832 | 48,30 | 40 k USD |
| 2024-01-25 | Yen Kristen | SEE REMARKS | Sell | 397 | 48,30 | 19 k USD |
| 2024-01-25 | Yen Kristen | SEE REMARKS | Sell | 397 | 48,30 | 19 k USD |
| 2024-01-08 | MARIO ERNEST | Director | Sell | 4 k | 0,00 | 0 USD |
| 2024-01-08 | MARIO ERNEST | Director | Sell | 4 k | 0,00 | 0 USD |
| 2024-01-04 | Anish Bhatnagar | Chief Executive Officer | Buy | 150 k | 0,00 | 0 USD |
| 2024-01-04 | Hirano Patricia C | See Remarks | Buy | 24 k | 0,00 | 0 USD |
| 2024-01-04 | Mackaness James H | Chief Financial Officer | Buy | 56 k | 0,00 | 0 USD |
| 2024-01-04 | Anish Bhatnagar | Chief Executive Officer | Buy | 150 k | 0,00 | 0 USD |
| 2024-01-04 | Hirano Patricia C | See Remarks | Buy | 24 k | 0,00 | 0 USD |
| 2024-01-04 | Mackaness James H | Chief Financial Officer | Buy | 56 k | 0,00 | 0 USD |
| 2024-01-04 | Yen Kristen | See Remarks | Buy | 24 k | 0,00 | 0 USD |
| 2024-01-04 | Yen Kristen | See Remarks | Buy | 24 k | 0,00 | 0 USD |
| 2023-12-14 | Hirano Patricia C | See Remarks | Sell | 1 k | 36,49 | 50 k USD |
| 2023-12-14 | Hirano Patricia C | See Remarks | Sell | 1 k | 36,49 | 50 k USD |
| 2023-12-13 | Hirano Patricia C | See Remarks | Sell | 5 k | 38,79 | 190 k USD |
| 2023-12-13 | Hirano Patricia C | See Remarks | Sell | 5 k | 38,79 | 190 k USD |
| 2023-12-13 | Yen Kristen | See Remarks | Buy | 13 k | 2,60 | 35 k USD |
| 2023-12-13 | Yen Kristen | See Remarks | Buy | 5 k | 2,41 | 11 k USD |
| 2023-12-13 | Yen Kristen | See Remarks | Sell | 18 k | 37,76 | 677 k USD |
| 2023-12-13 | Yen Kristen | See Remarks | Buy | 13 k | 2,60 | 35 k USD |
| 2023-12-13 | Yen Kristen | See Remarks | Buy | 5 k | 2,41 | 11 k USD |
| 2023-12-13 | Yen Kristen | See Remarks | Sell | 18 k | 37,76 | 677 k USD |
| 2023-12-12 | Yen Kristen | See Remarks | Sell | 4 k | 36,64 | 133 k USD |
| 2023-12-12 | Yen Kristen | See Remarks | Sell | 16 k | 37,02 | 603 k USD |
| 2023-12-12 | Yen Kristen | See Remarks | Sell | 4 k | 36,64 | 133 k USD |
| 2023-12-12 | Yen Kristen | See Remarks | Sell | 16 k | 37,02 | 603 k USD |
| 2023-12-11 | Anish Bhatnagar | Chief Executive Officer | Sell | 51 k | 35,26 | 1.8 mn USD |
| 2023-12-11 | Anish Bhatnagar | Chief Executive Officer | Sell | 35 k | 36,00 | 1.3 mn USD |
| 2023-12-11 | Anish Bhatnagar | Chief Executive Officer | Sell | 7 k | 37,01 | 256 k USD |
| 2023-12-11 | Mackaness James H | Chief Financial Officer | Buy | 15 k | 2,60 | 39 k USD |
| 2023-12-11 | Mackaness James H | Chief Financial Officer | Sell | 6 k | 35,49 | 222 k USD |
| 2023-12-11 | Mackaness James H | Chief Financial Officer | Sell | 12 k | 36,16 | 448 k USD |
| 2023-12-11 | Mackaness James H | Chief Financial Officer | Sell | 14 k | 37,06 | 513 k USD |
| 2023-12-11 | Mackaness James H | Chief Financial Officer | Buy | 15 k | 2,60 | 39 k USD |
| 2023-12-11 | Mackaness James H | Chief Financial Officer | Sell | 6 k | 35,49 | 222 k USD |
| 2023-12-11 | Mackaness James H | Chief Financial Officer | Sell | 12 k | 36,16 | 448 k USD |
| 2023-12-11 | Mackaness James H | Chief Financial Officer | Sell | 14 k | 37,06 | 513 k USD |
| 2023-12-11 | Anish Bhatnagar | Chief Executive Officer | Sell | 51 k | 35,26 | 1.8 mn USD |
| 2023-12-11 | Anish Bhatnagar | Chief Executive Officer | Sell | 35 k | 36,00 | 1.3 mn USD |
| 2023-12-11 | Anish Bhatnagar | Chief Executive Officer | Sell | 7 k | 37,01 | 256 k USD |
| 2023-11-30 | Anish Bhatnagar | Chief Executive Officer | Sell | 28 k | 28,65 | 794 k USD |
| 2023-11-30 | Hirano Patricia C | See Remarks | Sell | 4 k | 28,65 | 110 k USD |
| 2023-11-30 | MARIO ERNEST | Director | Sell | 9 k | 0,00 | 0 USD |
| 2023-11-30 | Mackaness James H | Chief Financial Officer | Sell | 4 k | 28,65 | 120 k USD |
| 2023-11-30 | Anish Bhatnagar | Chief Executive Officer | Sell | 28 k | 28,65 | 794 k USD |
| 2023-11-30 | Hirano Patricia C | See Remarks | Sell | 4 k | 28,65 | 110 k USD |
| 2023-11-30 | Mackaness James H | Chief Financial Officer | Sell | 4 k | 28,65 | 120 k USD |
| 2023-11-30 | Yen Kristen | See Remarks | Sell | 4 k | 28,65 | 114 k USD |
| 2023-11-30 | MARIO ERNEST | Director | Sell | 9 k | 0,00 | 0 USD |
| 2023-11-30 | Yen Kristen | See Remarks | Sell | 4 k | 28,65 | 114 k USD |
| 2023-11-29 | Anish Bhatnagar | Chief Executive Officer | Sell | 14 k | 27,43 | 393 k USD |
| 2023-11-29 | Anish Bhatnagar | Chief Executive Officer | Sell | 14 k | 28,26 | 382 k USD |
| 2023-11-29 | Hirano Patricia C | See Remarks | Sell | 2 k | 27,43 | 54 k USD |
| 2023-11-29 | Hirano Patricia C | See Remarks | Sell | 2 k | 28,26 | 53 k USD |
| 2023-11-29 | Mackaness James H | Chief Financial Officer | Sell | 2 k | 27,43 | 59 k USD |
| 2023-11-29 | Mackaness James H | Chief Financial Officer | Sell | 2 k | 28,26 | 58 k USD |
| 2023-11-29 | Hirano Patricia C | See Remarks | Sell | 2 k | 28,26 | 53 k USD |
| 2023-11-29 | Anish Bhatnagar | Chief Executive Officer | Sell | 14 k | 27,43 | 393 k USD |
| 2023-11-29 | Anish Bhatnagar | Chief Executive Officer | Sell | 14 k | 28,26 | 382 k USD |
| 2023-11-29 | Hirano Patricia C | See Remarks | Sell | 2 k | 27,43 | 54 k USD |
| 2023-11-29 | Mackaness James H | Chief Financial Officer | Sell | 2 k | 27,43 | 59 k USD |
| 2023-11-29 | Mackaness James H | Chief Financial Officer | Sell | 2 k | 28,26 | 58 k USD |
| 2023-11-29 | Yen Kristen | See Remarks | Sell | 2 k | 27,43 | 56 k USD |
| 2023-11-29 | Yen Kristen | See Remarks | Sell | 2 k | 28,26 | 55 k USD |
| 2023-11-29 | Yen Kristen | See Remarks | Sell | 2 k | 27,43 | 56 k USD |
| 2023-11-29 | Yen Kristen | See Remarks | Sell | 2 k | 28,26 | 55 k USD |
| 2023-11-28 | Anish Bhatnagar | Chief Executive Officer | Sell | 21 k | 27,03 | 573 k USD |
| 2023-11-28 | Anish Bhatnagar | Chief Executive Officer | Sell | 4 k | 27,59 | 123 k USD |
| 2023-11-28 | Hirano Patricia C | See Remarks | Sell | 3 k | 27,03 | 79 k USD |
| 2023-11-28 | Hirano Patricia C | See Remarks | Sell | 615 | 27,59 | 17 k USD |
| 2023-11-28 | Mackaness James H | Chief Financial Officer | Sell | 3 k | 27,03 | 87 k USD |
| 2023-11-28 | Mackaness James H | Chief Financial Officer | Sell | 673 | 27,59 | 19 k USD |
| 2023-11-28 | Anish Bhatnagar | Chief Executive Officer | Sell | 21 k | 27,03 | 573 k USD |
| 2023-11-28 | Anish Bhatnagar | Chief Executive Officer | Sell | 4 k | 27,59 | 123 k USD |
| 2023-11-28 | Hirano Patricia C | See Remarks | Sell | 3 k | 27,03 | 79 k USD |
| 2023-11-28 | Hirano Patricia C | See Remarks | Sell | 615 | 27,59 | 17 k USD |
| 2023-11-28 | Mackaness James H | Chief Financial Officer | Sell | 3 k | 27,03 | 87 k USD |
| 2023-11-28 | Mackaness James H | Chief Financial Officer | Sell | 673 | 27,59 | 19 k USD |
| 2023-11-28 | Yen Kristen | See Remarks | Sell | 3 k | 27,03 | 82 k USD |
| 2023-11-28 | Yen Kristen | See Remarks | Sell | 637 | 27,59 | 18 k USD |
| 2023-11-28 | Yen Kristen | See Remarks | Sell | 3 k | 27,03 | 82 k USD |
| 2023-11-28 | Yen Kristen | See Remarks | Sell | 637 | 27,59 | 18 k USD |
| 2023-10-20 | Anish Bhatnagar | Chief Executive Officer | Buy | 4 k | 4,50 | 18 k USD |
| 2023-10-20 | Anish Bhatnagar | Chief Executive Officer | Buy | 2 k | 1,75 | 4 k USD |
| 2023-10-20 | Anish Bhatnagar | Chief Executive Officer | Buy | 4 k | 2,50 | 9 k USD |
| 2023-10-20 | Anish Bhatnagar | Chief Executive Officer | Buy | 4 k | 4,50 | 18 k USD |
| 2023-10-20 | Anish Bhatnagar | Chief Executive Officer | Buy | 2 k | 1,75 | 4 k USD |
| 2023-10-20 | Anish Bhatnagar | Chief Executive Officer | Buy | 4 k | 2,50 | 9 k USD |
| 2023-10-02 | Mackaness James H | Chief Financial Officer | Buy | 3 k | 4,50 | 12 k USD |
| 2023-10-02 | Mackaness James H | Chief Financial Officer | Buy | 2 k | 1,75 | 4 k USD |
| 2023-10-02 | Mackaness James H | Chief Financial Officer | Buy | 4 k | 2,50 | 9 k USD |
| 2023-10-02 | Mackaness James H | Chief Financial Officer | Buy | 3 k | 4,50 | 12 k USD |
| 2023-10-02 | Mackaness James H | Chief Financial Officer | Buy | 2 k | 1,75 | 4 k USD |
| 2023-10-02 | Mackaness James H | Chief Financial Officer | Buy | 4 k | 2,50 | 9 k USD |
| 2023-10-02 | Vivo Opportunity, LLC | 10% owner | Buy | 5.2 mn | 2,50 | 13.0 mn USD |
| 2023-10-02 | Vivo Opportunity, LLC | 10% owner | Buy | 5.2 mn | 2,50 | 13.0 mn USD |
| 2023-10-02 | Vivo Opportunity, LLC | 10% owner | Buy | 5.2 mn | 2,50 | 13.0 mn USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | Carlyle Group Inc. | 10% owner | Buy | 330 k | 1,75 | 577 k USD |
| 2023-09-28 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 250 k | 20,00 | 5.0 mn USD |
| 2023-09-28 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 250 k | 20,00 | 5.0 mn USD |
| 2023-09-28 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 250 k | 20,00 | 5.0 mn USD |
| 2023-09-28 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 250 k | 20,00 | 5.0 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 28 k | 16,00 | 444 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 6 k | 7,65 | 44 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 14 k | 8,30 | 114 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 5 k | 9,52 | 52 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 38 k | 11,05 | 419 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 78 k | 11,81 | 919 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 43 k | 12,84 | 550 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 31 k | 13,92 | 425 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 3 k | 14,61 | 49 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 75 k | 17,28 | 1.3 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 53 k | 18,24 | 961 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 89 k | 19,11 | 1.7 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 118 k | 20,03 | 2.4 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 37 k | 21,00 | 776 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 6 k | 7,65 | 44 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 14 k | 8,30 | 114 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 5 k | 9,52 | 52 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 38 k | 11,05 | 419 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 78 k | 11,81 | 919 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 43 k | 12,84 | 550 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 31 k | 13,92 | 425 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 3 k | 14,61 | 49 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 28 k | 16,00 | 444 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 75 k | 17,28 | 1.3 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 53 k | 18,24 | 961 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 89 k | 19,11 | 1.7 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 118 k | 20,03 | 2.4 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 37 k | 21,00 | 776 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 6 k | 7,65 | 44 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 14 k | 8,30 | 114 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 5 k | 9,52 | 52 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 38 k | 11,05 | 419 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 78 k | 11,81 | 919 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 43 k | 12,84 | 550 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 31 k | 13,92 | 425 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 3 k | 14,61 | 49 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 28 k | 16,00 | 444 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 75 k | 17,28 | 1.3 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 53 k | 18,24 | 961 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 89 k | 19,11 | 1.7 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 118 k | 20,03 | 2.4 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 37 k | 21,00 | 776 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 6 k | 7,65 | 44 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 14 k | 8,30 | 114 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 5 k | 9,52 | 52 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 38 k | 11,05 | 419 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 78 k | 11,81 | 919 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 43 k | 12,84 | 550 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 31 k | 13,92 | 425 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 3 k | 14,61 | 49 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 28 k | 16,00 | 444 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 75 k | 17,28 | 1.3 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 53 k | 18,24 | 961 k USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 89 k | 19,11 | 1.7 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 118 k | 20,03 | 2.4 mn USD |
| 2023-09-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 37 k | 21,00 | 776 k USD |
| 2023-09-26 | Vivo Opportunity, LLC | 10% owner | Buy | 3.2 mn | 1,75 | 5.6 mn USD |
| 2023-09-26 | Vivo Opportunity, LLC | 10% owner | Buy | 3.2 mn | 1,75 | 5.6 mn USD |
| 2023-09-26 | Vivo Opportunity, LLC | 10% owner | Buy | 3.2 mn | 1,75 | 5.6 mn USD |
| 2023-06-06 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 200 | 5,93 | 1 k USD |
| 2023-06-06 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 200 | 5,93 | 1 k USD |
| 2023-06-06 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 200 | 5,93 | 1 k USD |
| 2023-06-06 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 200 | 5,93 | 1 k USD |
| 2023-06-05 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 78 k | 5,98 | 469 k USD |
| 2023-06-05 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 78 k | 5,98 | 469 k USD |
| 2023-06-05 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 78 k | 5,98 | 469 k USD |
| 2023-06-05 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 78 k | 5,98 | 469 k USD |
| 2023-06-02 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 65 k | 5,93 | 383 k USD |
| 2023-06-02 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 65 k | 5,93 | 383 k USD |
| 2023-06-02 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 65 k | 5,93 | 383 k USD |
| 2023-06-02 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 65 k | 5,93 | 383 k USD |
| 2023-06-01 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 8 k | 5,59 | 42 k USD |
| 2023-06-01 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 8 k | 5,59 | 42 k USD |
| 2023-06-01 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 8 k | 5,59 | 42 k USD |
| 2023-06-01 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 8 k | 5,59 | 42 k USD |
| 2023-05-31 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 10 k | 5,28 | 53 k USD |
| 2023-05-31 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 10 k | 5,28 | 53 k USD |
| 2023-05-31 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 10 k | 5,28 | 53 k USD |
| 2023-05-31 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 10 k | 5,28 | 53 k USD |
| 2023-05-30 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 18 k | 5,34 | 93 k USD |
| 2023-05-30 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 18 k | 5,34 | 93 k USD |
| 2023-05-30 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 18 k | 5,34 | 93 k USD |
| 2023-05-30 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 18 k | 5,34 | 93 k USD |
| 2023-05-26 | Anish Bhatnagar | Chief Executive Officer | Buy | 161 k | 0,00 | 0 USD |
| 2023-05-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 23 k | 5,27 | 119 k USD |
| 2023-05-26 | Hirano Patricia C | See Remarks | Buy | 28 k | 0,00 | 0 USD |
| 2023-05-26 | Mackaness James H | Chief Financial Officer | Buy | 29 k | 0,00 | 0 USD |
| 2023-05-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 23 k | 5,27 | 119 k USD |
| 2023-05-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 23 k | 5,27 | 119 k USD |
| 2023-05-26 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 23 k | 5,27 | 119 k USD |
| 2023-05-26 | Anish Bhatnagar | Chief Executive Officer | Buy | 161 k | 0,00 | 0 USD |
| 2023-05-26 | Hirano Patricia C | See Remarks | Buy | 28 k | 0,00 | 0 USD |
| 2023-05-26 | Mackaness James H | Chief Financial Officer | Buy | 29 k | 0,00 | 0 USD |
| 2023-05-26 | Yen Kristen | See Remarks | Buy | 29 k | 0,00 | 0 USD |
| 2023-05-26 | Yen Kristen | See Remarks | Buy | 29 k | 0,00 | 0 USD |
| 2023-05-25 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 38 k | 5,18 | 194 k USD |
| 2023-05-25 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 38 k | 5,18 | 194 k USD |
| 2023-05-25 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 38 k | 5,18 | 194 k USD |
| 2023-05-25 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 38 k | 5,18 | 194 k USD |
| 2023-05-24 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 25 k | 5,48 | 137 k USD |
| 2023-05-24 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 25 k | 5,48 | 137 k USD |
| 2023-05-24 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 25 k | 5,48 | 137 k USD |
| 2023-05-24 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 25 k | 5,48 | 137 k USD |
| 2023-05-23 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 28 k | 5,45 | 150 k USD |
| 2023-05-23 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 28 k | 5,45 | 150 k USD |
| 2023-05-23 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 28 k | 5,45 | 150 k USD |
| 2023-05-23 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 28 k | 5,45 | 150 k USD |
| 2023-05-22 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 27 k | 5,12 | 140 k USD |
| 2023-05-22 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 27 k | 5,12 | 140 k USD |
| 2023-05-22 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 27 k | 5,12 | 140 k USD |
| 2023-05-22 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 27 k | 5,12 | 140 k USD |
| 2023-05-19 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 25 k | 4,62 | 116 k USD |
| 2023-05-19 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 25 k | 4,62 | 116 k USD |
| 2023-05-19 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 25 k | 4,62 | 116 k USD |
| 2023-05-19 | PERCEPTIVE ADVISORS LLC | 10% owner | Buy | 25 k | 4,62 | 116 k USD |
| 2022-12-09 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,91 | 9 k USD |
| 2022-12-09 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,91 | 9 k USD |
| 2022-12-08 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,93 | 9 k USD |
| 2022-12-08 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,93 | 9 k USD |
| 2022-12-07 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,96 | 10 k USD |
| 2022-12-07 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,96 | 10 k USD |
| 2022-12-06 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-12-06 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-12-05 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,97 | 10 k USD |
| 2022-12-05 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,97 | 10 k USD |
| 2022-12-02 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,00 | 10 k USD |
| 2022-12-02 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,00 | 10 k USD |
| 2022-12-01 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,03 | 10 k USD |
| 2022-12-01 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,03 | 10 k USD |
| 2022-11-30 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-11-30 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-11-29 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,01 | 10 k USD |
| 2022-11-29 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,01 | 10 k USD |
| 2022-11-28 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,05 | 11 k USD |
| 2022-11-28 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,05 | 11 k USD |
| 2022-11-25 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,07 | 11 k USD |
| 2022-11-25 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,07 | 11 k USD |
| 2022-11-23 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,11 | 12 k USD |
| 2022-11-23 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,11 | 12 k USD |
| 2022-11-22 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,07 | 11 k USD |
| 2022-11-22 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,07 | 11 k USD |
| 2022-11-21 | SCHULER JACK W | 10% owner | Sell | 15 k | 1,13 | 16 k USD |
| 2022-11-21 | SCHULER JACK W | 10% owner | Sell | 15 k | 1,13 | 16 k USD |
| 2022-11-18 | SCHULER JACK W | 10% owner | Sell | 28 k | 1,15 | 33 k USD |
| 2022-11-18 | SCHULER JACK W | 10% owner | Sell | 28 k | 1,15 | 33 k USD |
| 2022-11-17 | SCHULER JACK W | 10% owner | Sell | 11 k | 1,15 | 13 k USD |
| 2022-11-17 | SCHULER JACK W | 10% owner | Sell | 11 k | 1,15 | 13 k USD |
| 2022-11-16 | SCHULER JACK W | 10% owner | Sell | 117 k | 1,26 | 147 k USD |
| 2022-11-16 | SCHULER JACK W | 10% owner | Sell | 117 k | 1,26 | 147 k USD |
| 2022-11-15 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,09 | 11 k USD |
| 2022-11-15 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,09 | 11 k USD |
| 2022-11-14 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,07 | 11 k USD |
| 2022-11-14 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,07 | 11 k USD |
| 2022-11-09 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,94 | 9 k USD |
| 2022-11-09 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,94 | 9 k USD |
| 2022-11-08 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-11-08 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-11-07 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-11-07 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-11-04 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-11-04 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-11-03 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,01 | 10 k USD |
| 2022-11-03 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,01 | 10 k USD |
| 2022-11-02 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,97 | 10 k USD |
| 2022-11-02 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,97 | 10 k USD |
| 2022-11-01 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-11-01 | SCHULER JACK W | 10% owner | Sell | 10 k | 0,99 | 10 k USD |
| 2022-10-31 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,00 | 10 k USD |
| 2022-10-31 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,00 | 10 k USD |
| 2022-10-28 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,08 | 11 k USD |
| 2022-10-28 | SCHULER JACK W | 10% owner | Sell | 10 k | 1,08 | 11 k USD |
| 2022-10-27 | SCHULER JACK W | 10% owner | Sell | 9 k | 1,16 | 11 k USD |
| 2022-10-27 | SCHULER JACK W | 10% owner | Sell | 9 k | 1,16 | 11 k USD |
| 2022-10-26 | SCHULER JACK W | 10% owner | Sell | 9 k | 1,26 | 11 k USD |
| 2022-10-26 | SCHULER JACK W | 10% owner | Sell | 9 k | 1,26 | 11 k USD |
| 2022-10-13 | SCHULER JACK W | 10% owner | Sell | 400 | 1,52 | 608 USD |
| 2022-10-13 | SCHULER JACK W | 10% owner | Sell | 400 | 1,52 | 608 USD |
| 2022-03-31 | Anish Bhatnagar | Chief Executive Officer | Buy | 60 k | – | – |
| 2022-03-31 | Hirano Patricia C | See Remarks | Buy | 20 k | – | – |
| 2022-03-31 | MARIO ERNEST | Director | Buy | 930 k | – | – |
| 2022-03-31 | MARIO ERNEST | Director | Buy | 930 k | – | – |
| 2022-03-31 | Mackaness James H | Chief Financial Officer | Buy | 40 k | – | – |
| 2022-03-31 | SCHULER JACK W | 10% owner | Buy | 4.0 mn | – | – |
| 2022-03-31 | Mackaness James H | Chief Financial Officer | Buy | 40 k | – | – |
| 2022-03-31 | Hirano Patricia C | See Remarks | Buy | 20 k | – | – |
| 2022-03-31 | Anish Bhatnagar | Chief Executive Officer | Buy | 60 k | – | – |
| 2022-03-31 | MARIO ERNEST | Director | Buy | 930 k | – | – |
| 2022-03-31 | MARIO ERNEST | Director | Buy | 930 k | – | – |
| 2022-03-31 | SCHULER JACK W | 10% owner | Buy | 4.0 mn | – | – |
| 2022-03-29 | Abingworth LLP | 10% owner | Buy | 7.7 mn | – | – |
| 2022-03-29 | Sinclair Andrew | Director | Buy | 7.7 mn | – | – |
| 2022-03-29 | Abingworth LLP | 10% owner | Buy | 7.7 mn | – | – |
| 2022-03-29 | Sinclair Andrew | Director | Buy | 7.7 mn | – | – |
| 2022-02-10 | SCHULER JACK W | 10% owner | Sell | 800 | 0,35 | 284 USD |
| 2022-02-10 | SCHULER JACK W | 10% owner | Sell | 800 | 0,35 | 284 USD |
| 2022-01-31 | Harris William G | Director | Buy | 42 k | 0,00 | 0 USD |
| 2022-01-31 | Harris William G | Director | Sell | 13 k | 0,36 | 5 k USD |
| 2022-01-31 | MARIO ERNEST | Director | Buy | 56 k | 0,36 | 20 k USD |
| 2022-01-31 | Volck Birgitte | Director | Buy | 36 k | 0,36 | 13 k USD |
| 2022-01-31 | Harris William G | Director | Buy | 42 k | 0,00 | 0 USD |
| 2022-01-31 | Harris William G | Director | Sell | 13 k | 0,36 | 5 k USD |
| 2022-01-31 | MARIO ERNEST | Director | Buy | 56 k | 0,36 | 20 k USD |
| 2022-01-31 | Volck Birgitte | Director | Buy | 36 k | 0,36 | 13 k USD |
| 2022-01-21 | Anish Bhatnagar | Chief Executive Officer | Sell | 39 k | 0,37 | 15 k USD |
| 2022-01-21 | Anish Bhatnagar | Chief Executive Officer | Sell | 39 k | 0,37 | 15 k USD |
| 2021-10-29 | Harris William G | Director | Buy | 20 k | 0,00 | 0 USD |
| 2021-10-29 | Harris William G | Director | Sell | 6 k | 0,74 | 5 k USD |
| 2021-10-29 | MARIO ERNEST | Director | Buy | 27 k | 0,00 | 0 USD |
| 2021-10-29 | Harris William G | Director | Buy | 20 k | 0,00 | 0 USD |
| 2021-10-29 | Harris William G | Director | Sell | 6 k | 0,74 | 5 k USD |
| 2021-10-29 | Volck Birgitte | Director | Buy | 17 k | 0,00 | 0 USD |
| 2021-10-29 | MARIO ERNEST | Director | Buy | 27 k | 0,00 | 0 USD |
| 2021-10-29 | Volck Birgitte | Director | Buy | 17 k | 0,00 | 0 USD |
| 2021-09-23 | SCHULER JACK W | 10% owner | Sell | 100 k | 0,88 | 88 k USD |
| 2021-09-23 | SCHULER JACK W | 10% owner | Sell | 100 k | 0,88 | 88 k USD |
| 2021-09-22 | SCHULER JACK W | 10% owner | Sell | 3 k | 0,87 | 2 k USD |
| 2021-09-22 | SCHULER JACK W | 10% owner | Sell | 3 k | 0,87 | 2 k USD |
| 2021-09-13 | Mackaness James H | Chief Financial Officer | Buy | 11 k | 0,89 | 10 k USD |
| 2021-09-13 | Mackaness James H | Chief Financial Officer | Buy | 11 k | 0,89 | 10 k USD |
| 2021-08-17 | SCHULER JACK W | 10% owner | Sell | 50 k | 0,78 | 39 k USD |
| 2021-08-17 | SCHULER JACK W | 10% owner | Sell | 50 k | 0,78 | 39 k USD |
| 2021-07-30 | Harris William G | Director | Buy | 16 k | 0,00 | 0 USD |
| 2021-07-30 | Harris William G | Director | Sell | 5 k | 0,91 | 5 k USD |
| 2021-07-30 | MARIO ERNEST | Director | Buy | 22 k | 0,91 | 20 k USD |
| 2021-07-30 | Harris William G | Director | Buy | 16 k | 0,00 | 0 USD |
| 2021-07-30 | Harris William G | Director | Sell | 5 k | 0,91 | 5 k USD |
| 2021-07-30 | MARIO ERNEST | Director | Buy | 22 k | 0,91 | 20 k USD |
| 2021-07-30 | Volck Birgitte | Director | Buy | 14 k | 0,91 | 13 k USD |
| 2021-07-30 | Volck Birgitte | Director | Buy | 14 k | 0,91 | 13 k USD |
| 2021-07-27 | SCHULER JACK W | 10% owner | Sell | 20 k | 0,86 | 17 k USD |
| 2021-07-27 | SCHULER JACK W | 10% owner | Sell | 20 k | 0,86 | 17 k USD |
| 2021-05-18 | SCHULER JACK W | 10% owner | Sell | 41 k | 1,03 | 42 k USD |
| 2021-05-18 | SCHULER JACK W | 10% owner | Sell | 41 k | 1,03 | 42 k USD |
| 2021-05-05 | SCHULER JACK W | 10% owner | Sell | 248 k | 1,14 | 283 k USD |
| 2021-05-05 | SCHULER JACK W | 10% owner | Sell | 248 k | 1,14 | 283 k USD |
| 2021-04-30 | SCHULER JACK W | 10% owner | Sell | 6 k | 1,25 | 7 k USD |
| 2021-04-30 | SCHULER JACK W | 10% owner | Sell | 6 k | 1,25 | 7 k USD |
| 2021-04-30 | Harris William G | Director | Buy | 12 k | 0,00 | 0 USD |
| 2021-04-30 | Harris William G | Director | Sell | 4 k | 1,21 | 5 k USD |
| 2021-04-30 | MARIO ERNEST | Director | Buy | 17 k | 1,21 | 20 k USD |
| 2021-04-30 | Volck Birgitte | Director | Buy | 11 k | 1,21 | 13 k USD |
| 2021-04-30 | Harris William G | Director | Buy | 12 k | 0,00 | 0 USD |
| 2021-04-30 | Harris William G | Director | Sell | 4 k | 1,21 | 5 k USD |
| 2021-04-30 | MARIO ERNEST | Director | Buy | 17 k | 1,21 | 20 k USD |
| 2021-04-30 | Volck Birgitte | Director | Buy | 11 k | 1,21 | 13 k USD |
| 2021-04-28 | SCHULER JACK W | 10% owner | Sell | 80 k | 1,26 | 101 k USD |
| 2021-04-28 | SCHULER JACK W | 10% owner | Sell | 80 k | 1,26 | 101 k USD |
| 2021-04-09 | SCHULER JACK W | 10% owner | Sell | 250 k | 1,20 | 300 k USD |
| 2021-04-09 | SCHULER JACK W | 10% owner | Sell | 250 k | 1,20 | 300 k USD |
| 2021-04-08 | SCHULER JACK W | 10% owner | Sell | 249 k | 1,21 | 301 k USD |
| 2021-04-08 | SCHULER JACK W | 10% owner | Sell | 249 k | 1,21 | 301 k USD |
| 2021-03-05 | SCHULER JACK W | 10% owner | Sell | 188 k | 2,67 | 502 k USD |
| 2021-03-05 | SCHULER JACK W | 10% owner | Sell | 188 k | 2,67 | 502 k USD |
| 2021-03-04 | SCHULER JACK W | 10% owner | Sell | 173 k | 2,62 | 453 k USD |
| 2021-03-04 | SCHULER JACK W | 10% owner | Sell | 173 k | 2,62 | 453 k USD |
| 2021-02-25 | SCHULER JACK W | 10% owner | Sell | 200 | 2,71 | 542 USD |
| 2021-02-25 | SCHULER JACK W | 10% owner | Sell | 200 | 2,71 | 542 USD |
| 2021-02-22 | SCHULER JACK W | 10% owner | Sell | 700 | 2,97 | 2 k USD |
| 2021-02-22 | SCHULER JACK W | 10% owner | Sell | 700 | 2,97 | 2 k USD |
| 2021-02-18 | SCHULER JACK W | 10% owner | Sell | 258 k | 2,95 | 763 k USD |
| 2021-02-18 | SCHULER JACK W | 10% owner | Sell | 258 k | 2,95 | 763 k USD |
| 2021-02-03 | SCHULER JACK W | 10% owner | Sell | 15 k | 2,13 | 31 k USD |
| 2021-02-03 | SCHULER JACK W | 10% owner | Sell | 15 k | 2,13 | 31 k USD |
| 2021-01-29 | Harris William G | Director | Buy | 7 k | 0,00 | 0 USD |
| 2021-01-29 | Harris William G | Director | Sell | 2 k | 1,96 | 4 k USD |
| 2021-01-29 | MARIO ERNEST | Director | Buy | 9 k | 0,00 | 0 USD |
| 2021-01-29 | MARIO ERNEST | Director | Buy | 9 k | 0,00 | 0 USD |
| 2021-01-29 | Volck Birgitte | Director | Buy | 6 k | 0,00 | 0 USD |
| 2021-01-29 | Harris William G | Director | Buy | 7 k | 0,00 | 0 USD |
| 2021-01-29 | Harris William G | Director | Sell | 2 k | 1,96 | 4 k USD |
| 2021-01-29 | Volck Birgitte | Director | Buy | 6 k | 0,00 | 0 USD |
| 2021-01-27 | SCHULER JACK W | 10% owner | Sell | 100 | 2,05 | 205 USD |
| 2021-01-27 | SCHULER JACK W | 10% owner | Sell | 100 | 2,05 | 205 USD |
| 2021-01-26 | SCHULER JACK W | 10% owner | Sell | 13 k | 2,05 | 26 k USD |
| 2021-01-26 | SCHULER JACK W | 10% owner | Sell | 13 k | 2,05 | 26 k USD |
| 2021-01-25 | SCHULER JACK W | 10% owner | Sell | 13 k | 2,06 | 26 k USD |
| 2021-01-25 | SCHULER JACK W | 10% owner | Sell | 13 k | 2,06 | 26 k USD |
| 2021-01-23 | Anish Bhatnagar | Chief Executive Officer | Sell | 36 k | 2,11 | 77 k USD |
| 2021-01-23 | Hirano Patricia C | See Remarks | Sell | 12 k | 2,11 | 25 k USD |
| 2021-01-23 | Anish Bhatnagar | Chief Executive Officer | Sell | 36 k | 2,11 | 77 k USD |
| 2021-01-23 | Hirano Patricia C | See Remarks | Sell | 12 k | 2,11 | 25 k USD |
| 2021-01-23 | Yen Kristen | See Remarks | Sell | 6 k | 2,11 | 12 k USD |
| 2021-01-23 | Yen Kristen | See Remarks | Sell | 6 k | 2,11 | 12 k USD |
| 2021-01-22 | SCHULER JACK W | 10% owner | Sell | 73 k | 2,09 | 152 k USD |
| 2021-01-22 | SCHULER JACK W | 10% owner | Sell | 73 k | 2,09 | 152 k USD |
| 2021-01-21 | SCHULER JACK W | 10% owner | Sell | 16 k | 2,10 | 33 k USD |
| 2021-01-21 | SCHULER JACK W | 10% owner | Sell | 16 k | 2,10 | 33 k USD |
| 2021-01-20 | SCHULER JACK W | 10% owner | Sell | 20 k | 2,10 | 42 k USD |
| 2021-01-20 | SCHULER JACK W | 10% owner | Sell | 20 k | 2,10 | 42 k USD |
| 2021-01-19 | SCHULER JACK W | 10% owner | Sell | 30 k | 2,05 | 61 k USD |
| 2021-01-19 | SCHULER JACK W | 10% owner | Sell | 30 k | 2,05 | 61 k USD |
| 2021-01-15 | SCHULER JACK W | 10% owner | Sell | 35 k | 2,11 | 74 k USD |
| 2021-01-15 | SCHULER JACK W | 10% owner | Sell | 35 k | 2,11 | 74 k USD |
| 2021-01-04 | SCHULER JACK W | 10% owner | Sell | 102 k | 1,99 | 203 k USD |
| 2021-01-04 | SCHULER JACK W | 10% owner | Sell | 102 k | 1,99 | 203 k USD |
| 2020-12-31 | SCHULER JACK W | 10% owner | Sell | 520 | 1,95 | 1 k USD |
| 2020-12-31 | SCHULER JACK W | 10% owner | Sell | 99 k | 1,90 | 188 k USD |
| 2020-12-31 | SCHULER JACK W | 10% owner | Sell | 520 | 1,95 | 1 k USD |
| 2020-12-31 | SCHULER JACK W | 10% owner | Sell | 99 k | 1,90 | 188 k USD |
| 2020-12-30 | SCHULER JACK W | 10% owner | Sell | 34 k | 1,95 | 66 k USD |
| 2020-12-30 | SCHULER JACK W | 10% owner | Sell | 34 k | 1,95 | 66 k USD |
| 2020-12-08 | SCHULER JACK W | 10% owner | Sell | 64 k | 1,85 | 118 k USD |
| 2020-12-08 | SCHULER JACK W | 10% owner | Sell | 64 k | 1,85 | 118 k USD |
| 2020-12-07 | SCHULER JACK W | 10% owner | Sell | 66 k | 1,91 | 125 k USD |
| 2020-12-07 | SCHULER JACK W | 10% owner | Sell | 66 k | 1,91 | 125 k USD |
| 2020-10-30 | Harris William G | Director | Buy | 8 k | 0,00 | 0 USD |
| 2020-10-30 | Harris William G | Director | Sell | 2 k | 1,74 | 4 k USD |
| 2020-10-30 | MARIO ERNEST | Director | Buy | 10 k | 1,74 | 17 k USD |
| 2020-10-30 | Volck Birgitte | Director | Buy | 7 k | 1,74 | 11 k USD |
| 2020-10-30 | Harris William G | Director | Buy | 8 k | 0,00 | 0 USD |
| 2020-10-30 | Harris William G | Director | Sell | 2 k | 1,74 | 4 k USD |
| 2020-10-30 | MARIO ERNEST | Director | Buy | 10 k | 1,74 | 17 k USD |
| 2020-10-30 | Volck Birgitte | Director | Buy | 7 k | 1,74 | 11 k USD |
| 2020-07-31 | COLLINSON STUART J | Director | Buy | 1 k | 1,72 | 2 k USD |
| 2020-07-31 | Harris William G | Director | Buy | 5 k | 1,72 | 9 k USD |
| 2020-07-31 | MARIO ERNEST | Director | Buy | 10 k | 1,72 | 17 k USD |
| 2020-07-31 | COLLINSON STUART J | Director | Buy | 1 k | 1,72 | 2 k USD |
| 2020-07-31 | Volck Birgitte | Director | Buy | 7 k | 1,72 | 11 k USD |
| 2020-07-31 | MARIO ERNEST | Director | Buy | 10 k | 1,72 | 17 k USD |
| 2020-07-31 | Harris William G | Director | Buy | 5 k | 1,72 | 9 k USD |
| 2020-07-31 | Volck Birgitte | Director | Buy | 7 k | 1,72 | 11 k USD |
| 2020-06-26 | Mackaness James H | Chief Financial Officer | Buy | 6 k | 1,65 | 10 k USD |
| 2020-06-26 | Mackaness James H | Chief Financial Officer | Buy | 6 k | 1,65 | 10 k USD |
| 2020-06-26 | Abingworth LLP | 10% owner | Buy | 3.3 mn | 1,65 | 5.5 mn USD |
| 2020-06-26 | Abingworth LLP | 10% owner | Buy | 3.3 mn | 1,65 | 5.5 mn USD |
| 2020-06-26 | Sinclair Andrew | Director | Buy | 3.3 mn | 1,65 | 5.5 mn USD |
| 2020-06-26 | Sinclair Andrew | Director | Buy | 3.3 mn | 1,65 | 5.5 mn USD |