Seagen Inc.
SGEN
Transaktioner
1000
Köp
356
Sälj
644
Nettoinsynsflöde
-72.6 mdr USD
Köpvärde minus säljvärde
Rapportanalys
Senast rapporterade siffror, automatiskt granskadeLäser senaste rapporten…
Aktiekurs och insynstransaktioner
Ingen prisdata ännuIngen prisserie har matchats mot detta bolag ännu.
Avkastning efter transaktion
Median-% efter transaktionsdatumKursserien för detta bolag rör sig i tick som är stora i förhållande till aktiekursen, så procentuell avkastning skulle domineras av avrundningsbrus snarare än av verkliga kursrörelser. Avkastningsstatistik visas därför inte.
Signalkorrelation
Månatligt nettoinsynsflöde vs avkastning–
Pearsonkorrelation mellan den signerade logaritmen av månatligt nettoinsynsköp och den månadens aktiekursavkastning, över 0 månader med aktivitet. Värden nära noll innebär att insynsflödet inte gav någon timinginformation för detta bolag.
Alla rapporterade transaktioner
1000 rader| Datum | Person | Position | Typ | Volym | Pris | Värde |
|---|---|---|---|---|---|---|
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 1.7 mn | 229,00 | 396.4 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 43.0 mn | 229,00 | 9.8 mdr USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 1.7 mn | 229,00 | 396.4 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 43.0 mn | 229,00 | 9.8 mdr USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 1.7 mn | 229,00 | 396.4 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 43.0 mn | 229,00 | 9.8 mdr USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 1.7 mn | 229,00 | 396.4 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 43.0 mn | 229,00 | 9.8 mdr USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 1.7 mn | 229,00 | 396.4 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 43.0 mn | 229,00 | 9.8 mdr USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 1.7 mn | 229,00 | 396.4 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 43.0 mn | 229,00 | 9.8 mdr USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 23 k | 229,00 | 5.3 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 1.7 mn | 229,00 | 396.4 mn USD |
| 2023-12-14 | BAKER BROS. ADVISORS LP | Director | Sell | 43.0 mn | 229,00 | 9.8 mdr USD |
| 2023-12-14 | DANSEY ROGER D | President, R&D & CMO | Sell | 38 k | 229,00 | 8.8 mn USD |
| 2023-12-14 | Epstein David R | CEO | Sell | 16 k | 229,00 | 3.8 mn USD |
| 2023-12-14 | GRYSKA DAVID W | Director | Sell | 49 k | 229,00 | 11.2 mn USD |
| 2023-12-14 | HIMES VAUGHN B | Chief Technical Officer | Sell | 15 k | 229,00 | 3.4 mn USD |
| 2023-12-14 | HIMES VAUGHN B | Chief Technical Officer | Sell | 119 k | 229,00 | 27.4 mn USD |
| 2023-12-14 | LIU JEAN I | Chief Legal Officer | Sell | 49 k | 229,00 | 11.2 mn USD |
| 2023-12-14 | LOVE TED W | Director | Sell | 4 k | 229,00 | 974 k USD |
| 2023-12-14 | Orwin John A | Director | Sell | 29 k | 229,00 | 6.6 mn USD |
| 2023-12-14 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 34 k | 229,00 | 7.7 mn USD |
| 2023-12-14 | SIMPSON TODD E | Chief Financial Officer | Sell | 93 k | 229,00 | 21.4 mn USD |
| 2023-12-14 | SWAIN SANDRA M | Director | Sell | 778 | 229,00 | 178 k USD |
| 2023-12-14 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 34 k | 229,00 | 7.7 mn USD |
| 2023-12-14 | DANSEY ROGER D | President, R&D & CMO | Sell | 38 k | 229,00 | 8.8 mn USD |
| 2023-12-14 | Orwin John A | Director | Sell | 29 k | 229,00 | 6.6 mn USD |
| 2023-12-14 | GRYSKA DAVID W | Director | Sell | 49 k | 229,00 | 11.2 mn USD |
| 2023-12-14 | Seth Alpna | Director | Sell | 13 k | 229,00 | 3.0 mn USD |
| 2023-12-14 | Epstein David R | CEO | Sell | 16 k | 229,00 | 3.8 mn USD |
| 2023-12-14 | WELCH DANIEL G | Director | Sell | 5 k | 229,00 | 1.1 mn USD |
| 2023-12-14 | WELCH DANIEL G | Director | Sell | 11 k | 229,00 | 2.5 mn USD |
| 2023-12-14 | LIU JEAN I | Chief Legal Officer | Sell | 49 k | 229,00 | 11.2 mn USD |
| 2023-12-14 | SWAIN SANDRA M | Director | Sell | 778 | 229,00 | 178 k USD |
| 2023-12-14 | LOVE TED W | Director | Sell | 4 k | 229,00 | 974 k USD |
| 2023-12-14 | SIMPSON TODD E | Chief Financial Officer | Sell | 93 k | 229,00 | 21.4 mn USD |
| 2023-12-14 | Simonian Nancy A | Director | Sell | 63 k | 229,00 | 14.4 mn USD |
| 2023-12-14 | HIMES VAUGHN B | Chief Technical Officer | Sell | 15 k | 229,00 | 3.4 mn USD |
| 2023-12-14 | HIMES VAUGHN B | Chief Technical Officer | Sell | 119 k | 229,00 | 27.4 mn USD |
| 2023-12-14 | Seth Alpna | Director | Sell | 13 k | 229,00 | 3.0 mn USD |
| 2023-12-14 | Simonian Nancy A | Director | Sell | 63 k | 229,00 | 14.4 mn USD |
| 2023-12-14 | WELCH DANIEL G | Director | Sell | 5 k | 229,00 | 1.1 mn USD |
| 2023-12-14 | WELCH DANIEL G | Director | Sell | 11 k | 229,00 | 2.5 mn USD |
| 2023-11-10 | Epstein David R | CEO | Sell | 11 k | 213,01 | 2.3 mn USD |
| 2023-11-10 | Epstein David R | CEO | Sell | 11 k | 213,01 | 2.3 mn USD |
| 2023-11-09 | HIMES VAUGHN B | Chief Technical Officer | Sell | 9 k | 213,31 | 1.8 mn USD |
| 2023-11-09 | HIMES VAUGHN B | Chief Technical Officer | Sell | 218 | 213,88 | 47 k USD |
| 2023-11-09 | HIMES VAUGHN B | Chief Technical Officer | Sell | 9 k | 213,31 | 1.8 mn USD |
| 2023-11-09 | HIMES VAUGHN B | Chief Technical Officer | Sell | 218 | 213,88 | 47 k USD |
| 2023-09-21 | DANSEY ROGER D | President, R&D & CMO | Sell | 71 | 206,50 | 15 k USD |
| 2023-09-21 | HIMES VAUGHN B | Chief Technical Officer | Sell | 80 | 206,50 | 17 k USD |
| 2023-09-21 | LIU JEAN I | Chief Legal Officer | Sell | 64 | 206,50 | 13 k USD |
| 2023-09-21 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 45 | 206,50 | 9 k USD |
| 2023-09-21 | SIMPSON TODD E | Chief Financial Officer | Sell | 80 | 206,50 | 17 k USD |
| 2023-09-21 | SIMPSON TODD E | Chief Financial Officer | Sell | 80 | 206,50 | 17 k USD |
| 2023-09-21 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 45 | 206,50 | 9 k USD |
| 2023-09-21 | LIU JEAN I | Chief Legal Officer | Sell | 64 | 206,50 | 13 k USD |
| 2023-09-21 | HIMES VAUGHN B | Chief Technical Officer | Sell | 80 | 206,50 | 17 k USD |
| 2023-09-21 | DANSEY ROGER D | President, R&D & CMO | Sell | 71 | 206,50 | 15 k USD |
| 2023-09-07 | HIMES VAUGHN B | Chief Technical Officer | Buy | 9 k | 44,09 | 387 k USD |
| 2023-09-07 | HIMES VAUGHN B | Chief Technical Officer | Sell | 9 k | 205,76 | 1.8 mn USD |
| 2023-09-07 | HIMES VAUGHN B | Chief Technical Officer | Buy | 9 k | 44,09 | 387 k USD |
| 2023-09-07 | HIMES VAUGHN B | Chief Technical Officer | Sell | 9 k | 205,76 | 1.8 mn USD |
| 2023-08-31 | DANSEY ROGER D | President, R&D & CMO | Sell | 4 k | 206,97 | 834 k USD |
| 2023-08-31 | HIMES VAUGHN B | Chief Technical Officer | Sell | 2 k | 206,97 | 372 k USD |
| 2023-08-31 | LIU JEAN I | Chief Legal Officer | Sell | 2 k | 206,97 | 392 k USD |
| 2023-08-31 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 555 | 206,97 | 115 k USD |
| 2023-08-31 | SIMPSON TODD E | Chief Financial Officer | Sell | 2 k | 206,97 | 439 k USD |
| 2023-08-31 | SIMPSON TODD E | Chief Financial Officer | Sell | 2 k | 206,97 | 439 k USD |
| 2023-08-31 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 555 | 206,97 | 115 k USD |
| 2023-08-31 | LIU JEAN I | Chief Legal Officer | Sell | 2 k | 206,97 | 392 k USD |
| 2023-08-31 | HIMES VAUGHN B | Chief Technical Officer | Sell | 2 k | 206,97 | 372 k USD |
| 2023-08-31 | DANSEY ROGER D | President, R&D & CMO | Sell | 4 k | 206,97 | 834 k USD |
| 2023-08-29 | DANSEY ROGER D | President, R&D & CMO | Sell | 1 k | 206,00 | 209 k USD |
| 2023-08-29 | HIMES VAUGHN B | Chief Technical Officer | Sell | 371 | 206,00 | 76 k USD |
| 2023-08-29 | LIU JEAN I | Chief Legal Officer | Sell | 405 | 206,00 | 83 k USD |
| 2023-08-29 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 438 | 206,00 | 90 k USD |
| 2023-08-29 | SIMPSON TODD E | Chief Financial Officer | Sell | 485 | 206,00 | 100 k USD |
| 2023-08-29 | LIU JEAN I | Chief Legal Officer | Sell | 405 | 206,00 | 83 k USD |
| 2023-08-29 | SIMPSON TODD E | Chief Financial Officer | Sell | 485 | 206,00 | 100 k USD |
| 2023-08-29 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 438 | 206,00 | 90 k USD |
| 2023-08-29 | HIMES VAUGHN B | Chief Technical Officer | Sell | 371 | 206,00 | 76 k USD |
| 2023-08-29 | DANSEY ROGER D | President, R&D & CMO | Sell | 1 k | 206,00 | 209 k USD |
| 2023-08-28 | DANSEY ROGER D | President, R&D & CMO | Buy | 2 k | 0,00 | 0 USD |
| 2023-08-28 | HIMES VAUGHN B | Chief Technical Officer | Buy | 937 | 0,00 | 0 USD |
| 2023-08-28 | LIU JEAN I | Chief Legal Officer | Buy | 1 k | 0,00 | 0 USD |
| 2023-08-28 | ROMP CHARLES R | EVP, Commercial U.S. | Buy | 1 k | 0,00 | 0 USD |
| 2023-08-28 | SIMPSON TODD E | Chief Financial Officer | Buy | 1 k | 0,00 | 0 USD |
| 2023-08-28 | LIU JEAN I | Chief Legal Officer | Buy | 1 k | 0,00 | 0 USD |
| 2023-08-28 | SIMPSON TODD E | Chief Financial Officer | Buy | 1 k | 0,00 | 0 USD |
| 2023-08-28 | ROMP CHARLES R | EVP, Commercial U.S. | Buy | 1 k | 0,00 | 0 USD |
| 2023-08-28 | HIMES VAUGHN B | Chief Technical Officer | Buy | 937 | 0,00 | 0 USD |
| 2023-08-28 | DANSEY ROGER D | President, R&D & CMO | Buy | 2 k | 0,00 | 0 USD |
| 2023-08-28 | WELCH DANIEL G | Director | Buy | 2 k | 135,63 | 246 k USD |
| 2023-08-28 | WELCH DANIEL G | Director | Sell | 2 k | 209,16 | 314 k USD |
| 2023-08-28 | WELCH DANIEL G | Director | Sell | 2 k | 209,01 | 379 k USD |
| 2023-08-28 | WELCH DANIEL G | Director | Sell | 2 k | 209,08 | 337 k USD |
| 2023-08-28 | WELCH DANIEL G | Director | Buy | 2 k | 135,63 | 246 k USD |
| 2023-08-28 | WELCH DANIEL G | Director | Sell | 2 k | 209,16 | 314 k USD |
| 2023-08-28 | WELCH DANIEL G | Director | Sell | 2 k | 209,01 | 379 k USD |
| 2023-08-28 | WELCH DANIEL G | Director | Sell | 2 k | 209,08 | 337 k USD |
| 2023-08-16 | DANSEY ROGER D | President, R&D & CMO | Sell | 2 k | 193,87 | 350 k USD |
| 2023-08-16 | DANSEY ROGER D | President, R&D & CMO | Sell | 6 k | 193,87 | 1.2 mn USD |
| 2023-08-16 | DANSEY ROGER D | President, R&D & CMO | Sell | 2 k | 193,87 | 455 k USD |
| 2023-08-16 | HIMES VAUGHN B | Chief Technical Officer | Sell | 658 | 193,87 | 128 k USD |
| 2023-08-16 | HIMES VAUGHN B | Chief Technical Officer | Sell | 869 | 193,87 | 168 k USD |
| 2023-08-16 | HIMES VAUGHN B | Chief Technical Officer | Sell | 1 k | 193,87 | 232 k USD |
| 2023-08-16 | LIU JEAN I | Chief Legal Officer | Sell | 717 | 193,87 | 139 k USD |
| 2023-08-16 | LIU JEAN I | Chief Legal Officer | Sell | 922 | 193,87 | 179 k USD |
| 2023-08-16 | LIU JEAN I | Chief Legal Officer | Sell | 1 k | 193,87 | 265 k USD |
| 2023-08-16 | ROMP CHARLES R | EVP, Commercial | Sell | 1 k | 193,87 | 265 k USD |
| 2023-08-16 | ROMP CHARLES R | EVP, Commercial | Sell | 988 | 193,87 | 192 k USD |
| 2023-08-16 | ROMP CHARLES R | EVP, Commercial | Sell | 777 | 193,87 | 151 k USD |
| 2023-08-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 1 k | 193,87 | 214 k USD |
| 2023-08-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 861 | 193,87 | 167 k USD |
| 2023-08-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 2 k | 193,87 | 299 k USD |
| 2023-08-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 1 k | 193,87 | 214 k USD |
| 2023-08-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 861 | 193,87 | 167 k USD |
| 2023-08-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 2 k | 193,87 | 299 k USD |
| 2023-08-16 | DANSEY ROGER D | President, R&D & CMO | Sell | 2 k | 193,87 | 350 k USD |
| 2023-08-16 | DANSEY ROGER D | President, R&D & CMO | Sell | 6 k | 193,87 | 1.2 mn USD |
| 2023-08-16 | DANSEY ROGER D | President, R&D & CMO | Sell | 2 k | 193,87 | 455 k USD |
| 2023-08-16 | ROMP CHARLES R | EVP, Commercial | Sell | 1 k | 193,87 | 265 k USD |
| 2023-08-16 | ROMP CHARLES R | EVP, Commercial | Sell | 988 | 193,87 | 192 k USD |
| 2023-08-16 | ROMP CHARLES R | EVP, Commercial | Sell | 777 | 193,87 | 151 k USD |
| 2023-08-16 | LIU JEAN I | Chief Legal Officer | Sell | 717 | 193,87 | 139 k USD |
| 2023-08-16 | LIU JEAN I | Chief Legal Officer | Sell | 922 | 193,87 | 179 k USD |
| 2023-08-16 | LIU JEAN I | Chief Legal Officer | Sell | 1 k | 193,87 | 265 k USD |
| 2023-08-16 | HIMES VAUGHN B | Chief Technical Officer | Sell | 658 | 193,87 | 128 k USD |
| 2023-08-16 | HIMES VAUGHN B | Chief Technical Officer | Sell | 869 | 193,87 | 168 k USD |
| 2023-08-16 | HIMES VAUGHN B | Chief Technical Officer | Sell | 1 k | 193,87 | 232 k USD |
| 2023-08-15 | DANSEY ROGER D | President, R&D & CMO | Buy | 26 k | 0,00 | 0 USD |
| 2023-08-15 | Epstein David R | Chief Executive Officer | Buy | 40 k | 0,00 | 0 USD |
| 2023-08-15 | HIMES VAUGHN B | Chief Technical Officer | Buy | 11 k | 0,00 | 0 USD |
| 2023-08-15 | LIU JEAN I | Chief Legal Officer | Buy | 13 k | 0,00 | 0 USD |
| 2023-08-15 | ROMP CHARLES R | EVP, Commercial | Buy | 13 k | 0,00 | 0 USD |
| 2023-08-15 | SIMPSON TODD E | Chief Financial Officer | Buy | 15 k | 0,00 | 0 USD |
| 2023-08-15 | SIMPSON TODD E | Chief Financial Officer | Buy | 15 k | 0,00 | 0 USD |
| 2023-08-15 | DANSEY ROGER D | President, R&D & CMO | Buy | 26 k | 0,00 | 0 USD |
| 2023-08-15 | ROMP CHARLES R | EVP, Commercial | Buy | 13 k | 0,00 | 0 USD |
| 2023-08-15 | LIU JEAN I | Chief Legal Officer | Buy | 13 k | 0,00 | 0 USD |
| 2023-08-15 | HIMES VAUGHN B | Chief Technical Officer | Buy | 11 k | 0,00 | 0 USD |
| 2023-08-15 | Epstein David R | Chief Executive Officer | Buy | 40 k | 0,00 | 0 USD |
| 2023-08-08 | LIU JEAN I | Chief Legal Officer | Sell | 11 k | 0,00 | 0 USD |
| 2023-08-08 | LIU JEAN I | Chief Legal Officer | Sell | 11 k | 0,00 | 0 USD |
| 2023-07-03 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 708 | 192,46 | 136 k USD |
| 2023-07-03 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 708 | 192,46 | 136 k USD |
| 2023-06-07 | HIMES VAUGHN B | Chief Technical Officer | Buy | 16 k | 41,04 | 665 k USD |
| 2023-06-07 | HIMES VAUGHN B | Chief Technical Officer | Sell | 16 k | 195,29 | 3.2 mn USD |
| 2023-06-07 | HIMES VAUGHN B | Chief Technical Officer | Buy | 16 k | 41,04 | 665 k USD |
| 2023-06-07 | HIMES VAUGHN B | Chief Technical Officer | Sell | 16 k | 195,29 | 3.2 mn USD |
| 2023-05-31 | Orwin John A | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | LOVE TED W | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | GRYSKA DAVID W | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | LOVE TED W | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | Orwin John A | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | SWAIN SANDRA M | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | WELCH DANIEL G | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | SWAIN SANDRA M | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | Simonian Nancy A | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | Seth Alpna | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | GRYSKA DAVID W | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | Seth Alpna | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | Simonian Nancy A | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-31 | WELCH DANIEL G | Director | Buy | 2 k | 0,00 | 0 USD |
| 2023-05-16 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 349 | 189,86 | 66 k USD |
| 2023-05-16 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 349 | 189,86 | 66 k USD |
| 2023-05-15 | WELCH DANIEL G | Director | Buy | 2 k | 135,63 | 253 k USD |
| 2023-05-15 | WELCH DANIEL G | Director | Sell | 2 k | 200,02 | 373 k USD |
| 2023-05-15 | WELCH DANIEL G | Director | Buy | 2 k | 135,63 | 253 k USD |
| 2023-05-15 | WELCH DANIEL G | Director | Sell | 2 k | 200,02 | 373 k USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | WELCH DANIEL G | Director | Buy | 2 k | 64,38 | 122 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Sell | 2 k | 200,05 | 378 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Buy | 3 k | 160,33 | 508 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Sell | 3 k | 200,05 | 634 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Buy | 3 k | 147,50 | 511 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Sell | 3 k | 200,10 | 693 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Sell | 351 | 200,07 | 70 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Sell | 6 k | 200,07 | 1.2 mn USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 0,00 | 0 USD |
| 2023-05-02 | WELCH DANIEL G | Director | Buy | 2 k | 64,38 | 122 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Sell | 2 k | 200,05 | 378 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Buy | 3 k | 160,33 | 508 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Sell | 3 k | 200,05 | 634 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Buy | 3 k | 147,50 | 511 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Sell | 3 k | 200,10 | 693 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Sell | 351 | 200,07 | 70 k USD |
| 2023-05-02 | WELCH DANIEL G | Director | Sell | 6 k | 200,07 | 1.2 mn USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2.4 mn | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2.4 mn | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2.4 mn | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2.4 mn | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2.4 mn | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2.4 mn | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | HIMES VAUGHN B | Chief Technical Officer | Sell | 25 k | 0,00 | 0 USD |
| 2023-05-01 | WELCH DANIEL G | Director | Buy | 5 k | 64,38 | 332 k USD |
| 2023-05-01 | WELCH DANIEL G | Director | Sell | 5 k | 200,04 | 1.0 mn USD |
| 2023-05-01 | WELCH DANIEL G | Director | Buy | 2 k | 56,77 | 113 k USD |
| 2023-05-01 | WELCH DANIEL G | Director | Sell | 2 k | 200,12 | 398 k USD |
| 2023-05-01 | WELCH DANIEL G | Director | Sell | 295 | 200,06 | 59 k USD |
| 2023-05-01 | WELCH DANIEL G | Director | Sell | 5 k | 200,06 | 978 k USD |
| 2023-05-01 | HIMES VAUGHN B | Chief Technical Officer | Sell | 25 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 9 k | 36,70 | 321 k USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2.4 mn | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 209 k | 0,00 | 0 USD |
| 2023-05-01 | WELCH DANIEL G | Director | Buy | 5 k | 64,38 | 332 k USD |
| 2023-05-01 | WELCH DANIEL G | Director | Sell | 5 k | 200,04 | 1.0 mn USD |
| 2023-05-01 | WELCH DANIEL G | Director | Buy | 2 k | 56,77 | 113 k USD |
| 2023-05-01 | WELCH DANIEL G | Director | Sell | 2 k | 200,12 | 398 k USD |
| 2023-05-01 | WELCH DANIEL G | Director | Sell | 295 | 200,06 | 59 k USD |
| 2023-05-01 | WELCH DANIEL G | Director | Sell | 5 k | 200,06 | 978 k USD |
| 2023-04-17 | DANSEY ROGER D | President, R&D & CMO | Buy | 10 k | 72,64 | 726 k USD |
| 2023-04-17 | DANSEY ROGER D | President, R&D & CMO | Sell | 10 k | 205,95 | 2.1 mn USD |
| 2023-04-17 | LIU JEAN I | Chief Legal Officer | Buy | 5 k | 39,15 | 196 k USD |
| 2023-04-17 | LIU JEAN I | Chief Legal Officer | Sell | 5 k | 205,86 | 1.0 mn USD |
| 2023-04-17 | DANSEY ROGER D | President, R&D & CMO | Buy | 10 k | 72,64 | 726 k USD |
| 2023-04-17 | DANSEY ROGER D | President, R&D & CMO | Sell | 10 k | 205,95 | 2.1 mn USD |
| 2023-04-17 | LIU JEAN I | Chief Legal Officer | Buy | 5 k | 39,15 | 196 k USD |
| 2023-04-17 | LIU JEAN I | Chief Legal Officer | Sell | 5 k | 205,86 | 1.0 mn USD |
| 2023-04-10 | SIMPSON TODD E | Chief Financial Officer | Buy | 15 k | 46,37 | 695 k USD |
| 2023-04-10 | SIMPSON TODD E | Chief Financial Officer | Sell | 15 k | 204,14 | 3.1 mn USD |
| 2023-04-10 | SIMPSON TODD E | Chief Financial Officer | Buy | 40 k | 46,37 | 1.9 mn USD |
| 2023-04-10 | SIMPSON TODD E | Chief Financial Officer | Sell | 40 k | 204,74 | 8.3 mn USD |
| 2023-04-10 | SIMPSON TODD E | Chief Financial Officer | Buy | 15 k | 46,37 | 695 k USD |
| 2023-04-10 | SIMPSON TODD E | Chief Financial Officer | Sell | 15 k | 204,14 | 3.1 mn USD |
| 2023-04-10 | SIMPSON TODD E | Chief Financial Officer | Buy | 40 k | 46,37 | 1.9 mn USD |
| 2023-04-10 | SIMPSON TODD E | Chief Financial Officer | Sell | 40 k | 204,74 | 8.3 mn USD |
| 2023-04-06 | DANSEY ROGER D | President, R&D & CMO | Sell | 333 | 205,86 | 69 k USD |
| 2023-04-06 | HIMES VAUGHN B | Chief Technical Officer | Sell | 243 | 205,86 | 50 k USD |
| 2023-04-06 | LIU JEAN I | Chief Legal Officer | Sell | 174 | 205,86 | 36 k USD |
| 2023-04-06 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 133 | 205,86 | 27 k USD |
| 2023-04-06 | SIMPSON TODD E | Chief Financial Officer | Sell | 243 | 205,86 | 50 k USD |
| 2023-04-06 | DANSEY ROGER D | President, R&D & CMO | Sell | 333 | 205,86 | 69 k USD |
| 2023-04-06 | HIMES VAUGHN B | Chief Technical Officer | Sell | 243 | 205,86 | 50 k USD |
| 2023-04-06 | LIU JEAN I | Chief Legal Officer | Sell | 174 | 205,86 | 36 k USD |
| 2023-04-06 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 133 | 205,86 | 27 k USD |
| 2023-04-06 | SIMPSON TODD E | Chief Financial Officer | Sell | 243 | 205,86 | 50 k USD |
| 2023-04-05 | DANSEY ROGER D | President, R&D & CMO | Buy | 3 k | 0,00 | 0 USD |
| 2023-04-05 | DANSEY ROGER D | President, R&D & CMO | Buy | 3 k | 0,00 | 0 USD |
| 2023-04-05 | DANSEY ROGER D | President, R&D & CMO | Buy | 609 | 0,00 | 0 USD |
| 2023-04-05 | HIMES VAUGHN B | Chief Technical Officer | Buy | 609 | 0,00 | 0 USD |
| 2023-04-05 | LIU JEAN I | Chief Legal Officer | Buy | 435 | 0,00 | 0 USD |
| 2023-04-05 | ROMP CHARLES R | EVP, Commercial U.S. | Buy | 348 | 0,00 | 0 USD |
| 2023-04-05 | SIMPSON TODD E | Chief Financial Officer | Buy | 609 | 0,00 | 0 USD |
| 2023-04-05 | DANSEY ROGER D | President, R&D & CMO | Buy | 609 | 0,00 | 0 USD |
| 2023-04-05 | HIMES VAUGHN B | Chief Technical Officer | Buy | 609 | 0,00 | 0 USD |
| 2023-04-05 | LIU JEAN I | Chief Legal Officer | Buy | 435 | 0,00 | 0 USD |
| 2023-04-05 | ROMP CHARLES R | EVP, Commercial U.S. | Buy | 348 | 0,00 | 0 USD |
| 2023-04-05 | SIMPSON TODD E | Chief Financial Officer | Buy | 609 | 0,00 | 0 USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 995 | 38,82 | 39 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 995 | 200,11 | 199 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 6 k | 66,60 | 378 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 6 k | 200,71 | 1.1 mn USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 4 k | 66,60 | 238 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 4 k | 201,59 | 721 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 5 | 66,60 | 333 USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 5 | 202,49 | 1 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 7 k | 56,77 | 406 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 7 k | 202,51 | 1.4 mn USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 112 | 56,77 | 6 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 112 | 203,05 | 23 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 817 | 200,45 | 164 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 851 | 201,51 | 171 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 1 k | 202,54 | 219 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 3 k | 200,45 | 626 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 3 k | 201,51 | 668 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 4 k | 202,54 | 868 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 995 | 38,82 | 39 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 995 | 200,11 | 199 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 6 k | 66,60 | 378 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 6 k | 200,71 | 1.1 mn USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 4 k | 66,60 | 238 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 4 k | 201,59 | 721 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 5 | 66,60 | 333 USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 5 | 202,49 | 1 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 7 k | 56,77 | 406 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 7 k | 202,51 | 1.4 mn USD |
| 2023-04-03 | WELCH DANIEL G | Director | Buy | 112 | 56,77 | 6 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 112 | 203,05 | 23 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 817 | 200,45 | 164 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 851 | 201,51 | 171 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 1 k | 202,54 | 219 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 3 k | 200,45 | 626 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 3 k | 201,51 | 668 k USD |
| 2023-04-03 | WELCH DANIEL G | Director | Sell | 4 k | 202,54 | 868 k USD |
| 2023-04-01 | DANSEY ROGER D | President, R&D & CMO | Buy | 2 k | 0,00 | 0 USD |
| 2023-04-01 | HIMES VAUGHN B | Chief Technical Officer | Buy | 1 k | 0,00 | 0 USD |
| 2023-04-01 | LIU JEAN I | Chief Legal Officer | Buy | 1 k | 0,00 | 0 USD |
| 2023-04-01 | ROMP CHARLES R | EVP, Commercial U.S. | Buy | 1 k | 0,00 | 0 USD |
| 2023-04-01 | SIMPSON TODD E | Chief Financial Officer | Buy | 1 k | 0,00 | 0 USD |
| 2023-04-01 | SIMPSON TODD E | Chief Financial Officer | Buy | 1 k | 0,00 | 0 USD |
| 2023-04-01 | ROMP CHARLES R | EVP, Commercial U.S. | Buy | 1 k | 0,00 | 0 USD |
| 2023-04-01 | DANSEY ROGER D | President, R&D & CMO | Buy | 2 k | 0,00 | 0 USD |
| 2023-04-01 | HIMES VAUGHN B | Chief Technical Officer | Buy | 1 k | 0,00 | 0 USD |
| 2023-04-01 | LIU JEAN I | Chief Legal Officer | Buy | 1 k | 0,00 | 0 USD |
| 2023-03-16 | LIU JEAN I | Chief Legal Officer | Buy | 5 k | 39,15 | 196 k USD |
| 2023-03-16 | LIU JEAN I | Chief Legal Officer | Sell | 5 k | 199,90 | 1000 k USD |
| 2023-03-16 | LIU JEAN I | Chief Legal Officer | Buy | 5 k | 39,15 | 196 k USD |
| 2023-03-16 | LIU JEAN I | Chief Legal Officer | Sell | 5 k | 199,90 | 1000 k USD |
| 2023-03-15 | DANSEY ROGER D | President, R&D & CMO | Buy | 10 k | 72,64 | 726 k USD |
| 2023-03-15 | DANSEY ROGER D | President, R&D & CMO | Sell | 10 k | 199,81 | 2.0 mn USD |
| 2023-03-15 | DANSEY ROGER D | President, R&D & CMO | Buy | 10 k | 72,64 | 726 k USD |
| 2023-03-15 | DANSEY ROGER D | President, R&D & CMO | Sell | 10 k | 199,81 | 2.0 mn USD |
| 2023-03-15 | WELCH DANIEL G | Director | Buy | 2 k | 38,82 | 79 k USD |
| 2023-03-15 | WELCH DANIEL G | Director | Sell | 2 k | 200,05 | 408 k USD |
| 2023-03-15 | WELCH DANIEL G | Director | Sell | 320 | 200,05 | 64 k USD |
| 2023-03-15 | WELCH DANIEL G | Director | Sell | 1 k | 200,05 | 249 k USD |
| 2023-03-15 | WELCH DANIEL G | Director | Buy | 2 k | 38,82 | 79 k USD |
| 2023-03-15 | WELCH DANIEL G | Director | Sell | 2 k | 200,05 | 408 k USD |
| 2023-03-15 | WELCH DANIEL G | Director | Sell | 320 | 200,05 | 64 k USD |
| 2023-03-15 | WELCH DANIEL G | Director | Sell | 1 k | 200,05 | 249 k USD |
| 2023-03-14 | WELCH DANIEL G | Director | Buy | 470 | 38,82 | 18 k USD |
| 2023-03-14 | WELCH DANIEL G | Director | Sell | 74 | 200,00 | 15 k USD |
| 2023-03-14 | WELCH DANIEL G | Director | Sell | 470 | 200,00 | 94 k USD |
| 2023-03-14 | WELCH DANIEL G | Director | Sell | 288 | 200,00 | 58 k USD |
| 2023-03-14 | WELCH DANIEL G | Director | Sell | 74 | 200,00 | 15 k USD |
| 2023-03-14 | WELCH DANIEL G | Director | Buy | 470 | 38,82 | 18 k USD |
| 2023-03-14 | WELCH DANIEL G | Director | Sell | 470 | 200,00 | 94 k USD |
| 2023-03-14 | WELCH DANIEL G | Director | Sell | 288 | 200,00 | 58 k USD |
| 2023-03-13 | DANSEY ROGER D | President, R&D & CMO | Buy | 2 k | 0,00 | 0 USD |
| 2023-03-13 | DANSEY ROGER D | President, R&D & CMO | Buy | 2 k | 0,00 | 0 USD |
| 2023-03-13 | WELCH DANIEL G | Director | Buy | 6 k | 38,82 | 224 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Buy | 283 | 39,94 | 11 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 283 | 202,36 | 57 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Buy | 1 k | 39,94 | 54 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 1 k | 201,53 | 272 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Buy | 8 k | 39,94 | 305 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 8 k | 200,30 | 1.5 mn USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 2 k | 200,20 | 420 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 214 | 201,53 | 43 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 44 | 202,35 | 9 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 6 k | 200,06 | 1.2 mn USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 8 k | 200,20 | 1.6 mn USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 808 | 201,53 | 163 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 173 | 202,36 | 35 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Buy | 6 k | 38,82 | 224 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Buy | 283 | 39,94 | 11 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 283 | 202,36 | 57 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Buy | 1 k | 39,94 | 54 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 1 k | 201,53 | 272 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Buy | 8 k | 39,94 | 305 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 8 k | 200,30 | 1.5 mn USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 2 k | 200,20 | 420 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 214 | 201,53 | 43 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 44 | 202,35 | 9 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 6 k | 200,06 | 1.2 mn USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 8 k | 200,20 | 1.6 mn USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 808 | 201,53 | 163 k USD |
| 2023-03-13 | WELCH DANIEL G | Director | Sell | 173 | 202,36 | 35 k USD |
| 2023-03-09 | SIMPSON TODD E | Chief Financial Officer | Buy | 43 k | 45,30 | 1.9 mn USD |
| 2023-03-09 | SIMPSON TODD E | Chief Financial Officer | Sell | 10 k | 175,89 | 1.8 mn USD |
| 2023-03-09 | SIMPSON TODD E | Chief Financial Officer | Sell | 26 k | 176,71 | 4.7 mn USD |
| 2023-03-09 | SIMPSON TODD E | Chief Financial Officer | Sell | 6 k | 177,37 | 1.1 mn USD |
| 2023-03-09 | SIMPSON TODD E | Chief Financial Officer | Buy | 43 k | 45,30 | 1.9 mn USD |
| 2023-03-09 | SIMPSON TODD E | Chief Financial Officer | Sell | 10 k | 175,89 | 1.8 mn USD |
| 2023-03-09 | SIMPSON TODD E | Chief Financial Officer | Sell | 26 k | 176,71 | 4.7 mn USD |
| 2023-03-09 | SIMPSON TODD E | Chief Financial Officer | Sell | 6 k | 177,37 | 1.1 mn USD |
| 2023-03-02 | HIMES VAUGHN B | Chief Technical Officer | Sell | 14 k | 177,07 | 2.4 mn USD |
| 2023-03-02 | HIMES VAUGHN B | Chief Technical Officer | Buy | 14 k | 41,04 | 555 k USD |
| 2023-03-02 | HIMES VAUGHN B | Chief Technical Officer | Buy | 3 k | 41,04 | 110 k USD |
| 2023-03-02 | HIMES VAUGHN B | Chief Technical Officer | Sell | 3 k | 177,92 | 479 k USD |
| 2023-03-02 | HIMES VAUGHN B | Chief Technical Officer | Buy | 14 k | 41,04 | 555 k USD |
| 2023-03-02 | HIMES VAUGHN B | Chief Technical Officer | Sell | 14 k | 177,07 | 2.4 mn USD |
| 2023-03-02 | HIMES VAUGHN B | Chief Technical Officer | Buy | 3 k | 41,04 | 110 k USD |
| 2023-03-02 | HIMES VAUGHN B | Chief Technical Officer | Sell | 3 k | 177,92 | 479 k USD |
| 2023-02-27 | SIMPSON TODD E | Chief Financial Officer | Sell | 20 k | 182,53 | 3.7 mn USD |
| 2023-02-27 | SIMPSON TODD E | Chief Financial Officer | Sell | 20 k | 182,53 | 3.7 mn USD |
| 2023-02-16 | LIU JEAN I | Chief Legal Officer | Buy | 5 k | 39,15 | 196 k USD |
| 2023-02-16 | LIU JEAN I | Chief Legal Officer | Sell | 5 k | 155,00 | 775 k USD |
| 2023-02-16 | SIMPSON TODD E | Chief Financial Officer | Buy | 40 k | 39,15 | 1.6 mn USD |
| 2023-02-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 40 k | 160,00 | 6.4 mn USD |
| 2023-02-16 | LIU JEAN I | Chief Legal Officer | Buy | 5 k | 39,15 | 196 k USD |
| 2023-02-16 | LIU JEAN I | Chief Legal Officer | Sell | 5 k | 155,00 | 775 k USD |
| 2023-02-16 | SIMPSON TODD E | Chief Financial Officer | Buy | 40 k | 39,15 | 1.6 mn USD |
| 2023-02-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 40 k | 160,00 | 6.4 mn USD |
| 2023-02-15 | DANSEY ROGER D | President, R&D & CMO | Buy | 10 k | 72,64 | 726 k USD |
| 2023-02-15 | DANSEY ROGER D | President, R&D & CMO | Sell | 200 | 138,62 | 28 k USD |
| 2023-02-15 | DANSEY ROGER D | President, R&D & CMO | Sell | 7 k | 140,55 | 1.0 mn USD |
| 2023-02-15 | DANSEY ROGER D | President, R&D & CMO | Sell | 3 k | 141,04 | 369 k USD |
| 2023-02-15 | DANSEY ROGER D | President, R&D & CMO | Buy | 10 k | 72,64 | 726 k USD |
| 2023-02-15 | DANSEY ROGER D | President, R&D & CMO | Sell | 200 | 138,62 | 28 k USD |
| 2023-02-15 | DANSEY ROGER D | President, R&D & CMO | Sell | 7 k | 140,55 | 1.0 mn USD |
| 2023-02-15 | DANSEY ROGER D | President, R&D & CMO | Sell | 3 k | 141,04 | 369 k USD |
| 2023-02-13 | GRYSKA DAVID W | Director | Buy | 9 k | 36,70 | 321 k USD |
| 2023-02-13 | GRYSKA DAVID W | Director | Buy | 9 k | 36,70 | 321 k USD |
| 2023-02-02 | DANSEY ROGER D | President, R&D & CMO | Sell | 783 | 138,52 | 108 k USD |
| 2023-02-02 | DANSEY ROGER D | President, R&D & CMO | Sell | 783 | 138,52 | 108 k USD |
| 2023-01-24 | DANSEY ROGER D | President, R&D & CMO | Buy | 10 k | 72,64 | 726 k USD |
| 2023-01-24 | DANSEY ROGER D | President, R&D & CMO | Sell | 10 k | 135,00 | 1.4 mn USD |
| 2023-01-24 | LIU JEAN I | Chief Legal Officer | Buy | 5 k | 39,15 | 196 k USD |
| 2023-01-24 | LIU JEAN I | Chief Legal Officer | Sell | 5 k | 135,03 | 675 k USD |
| 2023-01-24 | LIU JEAN I | Chief Legal Officer | Buy | 5 k | 39,15 | 196 k USD |
| 2023-01-24 | LIU JEAN I | Chief Legal Officer | Sell | 5 k | 135,03 | 675 k USD |
| 2023-01-24 | DANSEY ROGER D | President, R&D & CMO | Buy | 10 k | 72,64 | 726 k USD |
| 2023-01-24 | DANSEY ROGER D | President, R&D & CMO | Sell | 10 k | 135,00 | 1.4 mn USD |
| 2023-01-17 | LIU JEAN I | Chief Legal Officer | Sell | 578 | 130,71 | 76 k USD |
| 2023-01-17 | LIU JEAN I | Chief Legal Officer | Sell | 578 | 130,71 | 76 k USD |
| 2023-01-05 | DANSEY ROGER D | President R&D & CMO | Buy | 8 k | 72,64 | 545 k USD |
| 2023-01-05 | DANSEY ROGER D | President R&D & CMO | Sell | 8 k | 135,00 | 1.0 mn USD |
| 2023-01-05 | LIU JEAN I | Chief Legal Officer | Buy | 5 k | 39,15 | 177 k USD |
| 2023-01-05 | LIU JEAN I | Chief Legal Officer | Sell | 5 k | 135,00 | 611 k USD |
| 2023-01-05 | LIU JEAN I | Chief Legal Officer | Buy | 5 k | 39,15 | 177 k USD |
| 2023-01-05 | LIU JEAN I | Chief Legal Officer | Sell | 5 k | 135,00 | 611 k USD |
| 2023-01-05 | DANSEY ROGER D | President R&D & CMO | Buy | 8 k | 72,64 | 545 k USD |
| 2023-01-05 | DANSEY ROGER D | President R&D & CMO | Sell | 8 k | 135,00 | 1.0 mn USD |
| 2023-01-04 | DANSEY ROGER D | President R&D & CMO | Buy | 3 k | 72,64 | 182 k USD |
| 2023-01-04 | DANSEY ROGER D | President R&D & CMO | Sell | 3 k | 135,00 | 338 k USD |
| 2023-01-04 | LIU JEAN I | Chief Legal Officer | Buy | 475 | 39,15 | 19 k USD |
| 2023-01-04 | LIU JEAN I | Chief Legal Officer | Sell | 475 | 135,00 | 64 k USD |
| 2023-01-04 | LIU JEAN I | Chief Legal Officer | Buy | 475 | 39,15 | 19 k USD |
| 2023-01-04 | LIU JEAN I | Chief Legal Officer | Sell | 475 | 135,00 | 64 k USD |
| 2023-01-04 | DANSEY ROGER D | President R&D & CMO | Buy | 3 k | 72,64 | 182 k USD |
| 2023-01-04 | DANSEY ROGER D | President R&D & CMO | Sell | 3 k | 135,00 | 338 k USD |
| 2022-12-20 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 1 k | 127,63 | 144 k USD |
| 2022-12-20 | ROMP CHARLES R | EVP, Commercial U.S. | Sell | 1 k | 127,63 | 144 k USD |
| 2022-12-14 | DANSEY ROGER D | President, Research and Develo | Buy | 597 | 72,64 | 43 k USD |
| 2022-12-14 | DANSEY ROGER D | President, Research and Develo | Sell | 597 | 135,00 | 81 k USD |
| 2022-12-14 | DANSEY ROGER D | President, Research and Develo | Buy | 9 k | 77,45 | 728 k USD |
| 2022-12-14 | DANSEY ROGER D | President, Research and Develo | Sell | 9 k | 135,00 | 1.3 mn USD |
| 2022-12-14 | DANSEY ROGER D | President, Research and Develo | Buy | 597 | 72,64 | 43 k USD |
| 2022-12-14 | DANSEY ROGER D | President, Research and Develo | Sell | 597 | 135,00 | 81 k USD |
| 2022-12-14 | DANSEY ROGER D | President, Research and Develo | Buy | 9 k | 77,45 | 728 k USD |
| 2022-12-14 | DANSEY ROGER D | President, Research and Develo | Sell | 9 k | 135,00 | 1.3 mn USD |
| 2022-12-12 | Simonian Nancy A | Director | Buy | 9 k | 36,70 | 321 k USD |
| 2022-12-12 | Simonian Nancy A | Director | Buy | 9 k | 36,70 | 321 k USD |
| 2022-11-17 | LIU JEAN I | Chief Legal Officer | Buy | 8 k | 34,20 | 285 k USD |
| 2022-11-17 | LIU JEAN I | Chief Legal Officer | Sell | 8 k | 131,05 | 1.1 mn USD |
| 2022-11-17 | LIU JEAN I | Chief Legal Officer | Buy | 8 k | 34,20 | 285 k USD |
| 2022-11-17 | LIU JEAN I | Chief Legal Officer | Sell | 8 k | 131,05 | 1.1 mn USD |
| 2022-11-14 | LIU JEAN I | Chief Legal Officer | Buy | 1 k | 76,86 | 100 k USD |
| 2022-11-14 | LIU JEAN I | Chief Legal Officer | Buy | 1 k | 76,86 | 100 k USD |
| 2022-11-11 | GRYSKA DAVID W | Director | Sell | 8 k | 129,10 | 968 k USD |
| 2022-11-11 | GRYSKA DAVID W | Director | Sell | 8 k | 129,10 | 968 k USD |
| 2022-11-09 | Epstein David R | Chief Executive Officer | Buy | 107 k | 0,00 | 0 USD |
| 2022-11-09 | SWAIN SANDRA M | Director | Buy | 778 | 0,00 | 0 USD |
| 2022-11-09 | Epstein David R | Chief Executive Officer | Buy | 107 k | 0,00 | 0 USD |
| 2022-11-09 | SWAIN SANDRA M | Director | Buy | 778 | 0,00 | 0 USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Buy | 5 k | 77,45 | 357 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Sell | 5 k | 135,00 | 622 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Buy | 3 k | 76,86 | 245 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Sell | 3 k | 135,00 | 431 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Buy | 2 k | 65,11 | 144 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Sell | 2 k | 135,00 | 298 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Buy | 5 k | 77,45 | 357 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Sell | 5 k | 135,00 | 622 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Buy | 3 k | 76,86 | 245 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Sell | 3 k | 135,00 | 431 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Buy | 2 k | 65,11 | 144 k USD |
| 2022-10-17 | DANSEY ROGER D | Interim CEO & CMO | Sell | 2 k | 135,00 | 298 k USD |
| 2022-08-31 | DANSEY ROGER D | Interim CEO & CMO | Sell | 806 | 154,41 | 124 k USD |
| 2022-08-31 | DANSEY ROGER D | Interim CEO & CMO | Sell | 184 | 154,41 | 28 k USD |
| 2022-08-31 | DANSEY ROGER D | Interim CEO & CMO | Sell | 4 k | 154,41 | 622 k USD |
| 2022-08-31 | HIMES VAUGHN B | Chief Technical Officer | Sell | 2 k | 154,41 | 277 k USD |
| 2022-08-31 | HIMES VAUGHN B | Chief Technical Officer | Sell | 2 k | 154,41 | 276 k USD |
| 2022-08-31 | LIU JEAN I | Chief Legal Officer | Sell | 2 k | 154,41 | 271 k USD |
| 2022-08-31 | LIU JEAN I | Chief Legal Officer | Sell | 2 k | 154,41 | 292 k USD |
| 2022-08-31 | ROMP CHARLES R | EVP, Commercial | Sell | 578 | 154,41 | 89 k USD |
| 2022-08-31 | ROMP CHARLES R | EVP, Commercial | Sell | 555 | 154,41 | 86 k USD |
| 2022-08-31 | SIMPSON TODD E | Chief Financial Officer | Sell | 2 k | 154,41 | 328 k USD |
| 2022-08-31 | SIMPSON TODD E | Chief Financial Officer | Sell | 2 k | 154,41 | 319 k USD |
| 2022-08-31 | LIU JEAN I | Chief Legal Officer | Sell | 2 k | 154,41 | 271 k USD |
| 2022-08-31 | LIU JEAN I | Chief Legal Officer | Sell | 2 k | 154,41 | 292 k USD |
| 2022-08-31 | DANSEY ROGER D | Interim CEO & CMO | Sell | 806 | 154,41 | 124 k USD |
| 2022-08-31 | DANSEY ROGER D | Interim CEO & CMO | Sell | 184 | 154,41 | 28 k USD |
| 2022-08-31 | DANSEY ROGER D | Interim CEO & CMO | Sell | 4 k | 154,41 | 622 k USD |
| 2022-08-31 | ROMP CHARLES R | EVP, Commercial | Sell | 578 | 154,41 | 89 k USD |
| 2022-08-31 | ROMP CHARLES R | EVP, Commercial | Sell | 555 | 154,41 | 86 k USD |
| 2022-08-31 | HIMES VAUGHN B | Chief Technical Officer | Sell | 2 k | 154,41 | 277 k USD |
| 2022-08-31 | HIMES VAUGHN B | Chief Technical Officer | Sell | 2 k | 154,41 | 276 k USD |
| 2022-08-31 | SIMPSON TODD E | Chief Financial Officer | Sell | 2 k | 154,41 | 328 k USD |
| 2022-08-31 | SIMPSON TODD E | Chief Financial Officer | Sell | 2 k | 154,41 | 319 k USD |
| 2022-08-16 | DANSEY ROGER D | Interim CEO & CMO | Sell | 2 k | 170,22 | 410 k USD |
| 2022-08-16 | DANSEY ROGER D | Interim CEO & CMO | Sell | 2 k | 170,22 | 315 k USD |
| 2022-08-16 | HIMES VAUGHN B | Chief Technical Officer | Sell | 658 | 170,22 | 112 k USD |
| 2022-08-16 | HIMES VAUGHN B | Chief Technical Officer | Sell | 869 | 170,22 | 148 k USD |
| 2022-08-16 | LIU JEAN I | Chief Legal Officer | Sell | 922 | 170,22 | 157 k USD |
| 2022-08-16 | LIU JEAN I | Chief Legal Officer | Sell | 717 | 170,22 | 122 k USD |
| 2022-08-16 | ROMP CHARLES R | EVP, Commercial | Sell | 777 | 170,22 | 132 k USD |
| 2022-08-16 | ROMP CHARLES R | EVP, Commercial | Sell | 988 | 170,22 | 168 k USD |
| 2022-08-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 861 | 170,22 | 147 k USD |
| 2022-08-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 1 k | 170,22 | 188 k USD |
| 2022-08-16 | DANSEY ROGER D | Interim CEO & CMO | Sell | 2 k | 170,22 | 410 k USD |
| 2022-08-16 | DANSEY ROGER D | Interim CEO & CMO | Sell | 2 k | 170,22 | 315 k USD |
| 2022-08-16 | HIMES VAUGHN B | Chief Technical Officer | Sell | 658 | 170,22 | 112 k USD |
| 2022-08-16 | HIMES VAUGHN B | Chief Technical Officer | Sell | 869 | 170,22 | 148 k USD |
| 2022-08-16 | LIU JEAN I | Chief Legal Officer | Sell | 922 | 170,22 | 157 k USD |
| 2022-08-16 | LIU JEAN I | Chief Legal Officer | Sell | 717 | 170,22 | 122 k USD |
| 2022-08-16 | ROMP CHARLES R | EVP, Commercial | Sell | 777 | 170,22 | 132 k USD |
| 2022-08-16 | ROMP CHARLES R | EVP, Commercial | Sell | 988 | 170,22 | 168 k USD |
| 2022-08-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 861 | 170,22 | 147 k USD |
| 2022-08-16 | SIMPSON TODD E | Chief Financial Officer | Sell | 1 k | 170,22 | 188 k USD |
| 2022-08-15 | DANSEY ROGER D | Interim CEO & CMO | Buy | 45 k | 0,00 | 0 USD |
| 2022-08-15 | HIMES VAUGHN B | Chief Technical Officer | Buy | 12 k | 0,00 | 0 USD |
| 2022-08-15 | LIU JEAN I | Chief Legal Officer | Buy | 14 k | 0,00 | 0 USD |
| 2022-08-15 | ROMP CHARLES R | EVP, Commercial | Buy | 14 k | 0,00 | 0 USD |
| 2022-08-15 | SIMPSON TODD E | Chief Financial Officer | Buy | 15 k | 0,00 | 0 USD |
| 2022-08-15 | DANSEY ROGER D | Interim CEO & CMO | Buy | 45 k | 0,00 | 0 USD |
| 2022-08-15 | HIMES VAUGHN B | Chief Technical Officer | Buy | 12 k | 0,00 | 0 USD |
| 2022-08-15 | LIU JEAN I | Chief Legal Officer | Buy | 14 k | 0,00 | 0 USD |
| 2022-08-15 | ROMP CHARLES R | EVP, Commercial | Buy | 14 k | 0,00 | 0 USD |
| 2022-08-15 | SIMPSON TODD E | Chief Financial Officer | Buy | 15 k | 0,00 | 0 USD |
| 2022-07-05 | ROMP CHARLES R | EVP, Commercial | Sell | 712 | 179,46 | 128 k USD |
| 2022-07-05 | ROMP CHARLES R | EVP, Commercial | Sell | 712 | 179,46 | 128 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Buy | 17 k | 65,11 | 1.1 mn USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Sell | 17 k | 180,00 | 3.1 mn USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Buy | 913 | 65,11 | 59 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Sell | 913 | 180,00 | 164 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Buy | 735 | 65,11 | 48 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Sell | 735 | 180,00 | 132 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Buy | 735 | 65,11 | 48 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Sell | 735 | 180,00 | 132 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Sell | 15 k | 180,00 | 2.7 mn USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Buy | 17 k | 65,11 | 1.1 mn USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Sell | 17 k | 180,00 | 3.1 mn USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Buy | 913 | 65,11 | 59 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Sell | 913 | 180,00 | 164 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Buy | 735 | 65,11 | 48 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Sell | 735 | 180,00 | 132 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Buy | 735 | 65,11 | 48 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Sell | 735 | 180,00 | 132 k USD |
| 2022-06-28 | DANSEY ROGER D | Chief Medical Officer | Sell | 15 k | 180,00 | 2.7 mn USD |
| 2022-06-17 | HIMES VAUGHN B | Chief Technical Officer | Buy | 1 k | 41,04 | 47 k USD |
| 2022-06-17 | HIMES VAUGHN B | Chief Technical Officer | Sell | 1 k | 160,00 | 181 k USD |
| 2022-06-17 | HIMES VAUGHN B | Chief Technical Officer | Buy | 1 k | 41,04 | 47 k USD |
| 2022-06-17 | HIMES VAUGHN B | Chief Technical Officer | Sell | 1 k | 160,00 | 181 k USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Buy | 8 k | 26,10 | 216 k USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Sell | 8 k | 136,40 | 1.1 mn USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Buy | 1 k | 26,10 | 34 k USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Sell | 1 k | 137,51 | 178 k USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Buy | 1 k | 26,10 | 33 k USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Sell | 1 k | 138,61 | 176 k USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Buy | 8 k | 26,10 | 216 k USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Sell | 8 k | 136,40 | 1.1 mn USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Buy | 1 k | 26,10 | 34 k USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Sell | 1 k | 137,51 | 178 k USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Buy | 1 k | 26,10 | 33 k USD |
| 2022-05-24 | HIMES VAUGHN B | Chief Technical Officer | Sell | 1 k | 138,61 | 176 k USD |
| 2022-05-16 | ROMP CHARLES R | EVP, Commercial | Sell | 333 | 134,21 | 45 k USD |
| 2022-05-16 | ROMP CHARLES R | EVP, Commercial | Sell | 333 | 134,21 | 45 k USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | GRYSKA DAVID W | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | LOVE TED W | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | Orwin John A | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | Simonian Nancy A | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | WELCH DANIEL G | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | LOVE TED W | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | Orwin John A | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | GRYSKA DAVID W | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | Seth Alpna | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | Seth Alpna | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | Simonian Nancy A | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-13 | WELCH DANIEL G | Director | Buy | 2 k | 0,00 | 0 USD |
| 2022-05-12 | SIEGALL CLAY B | President & CEO | Buy | 6 k | 26,10 | 168 k USD |
| 2022-05-12 | SIEGALL CLAY B | President & CEO | Sell | 6 k | 126,18 | 814 k USD |
| 2022-05-12 | SIEGALL CLAY B | President & CEO | Buy | 11 k | 26,10 | 276 k USD |
| 2022-05-12 | SIEGALL CLAY B | President & CEO | Sell | 11 k | 125,39 | 1.3 mn USD |
| 2022-05-12 | SIEGALL CLAY B | President & CEO | Sell | 11 k | 125,39 | 1.3 mn USD |
| 2022-05-12 | SIEGALL CLAY B | President & CEO | Buy | 6 k | 26,10 | 168 k USD |
| 2022-05-12 | SIEGALL CLAY B | President & CEO | Sell | 6 k | 126,18 | 814 k USD |
| 2022-05-12 | SIEGALL CLAY B | President & CEO | Buy | 11 k | 26,10 | 276 k USD |
| 2022-04-21 | DANSEY ROGER D | Chief Medical Officer | Sell | 652 | 144,15 | 94 k USD |
| 2022-04-21 | DANSEY ROGER D | Chief Medical Officer | Sell | 652 | 144,15 | 94 k USD |
| 2022-04-20 | DANSEY ROGER D | Chief Medical Officer | Sell | 787 | 144,32 | 114 k USD |
| 2022-04-20 | HIMES VAUGHN B | Chief Technical Officer | Sell | 574 | 144,32 | 83 k USD |
| 2022-04-20 | LIU JEAN I | Chief Legal Officer | Sell | 401 | 144,32 | 58 k USD |
| 2022-04-20 | ROMP CHARLES R | EVP, Commercial | Sell | 319 | 144,32 | 46 k USD |
| 2022-04-20 | SIEGALL CLAY B | President & CEO | Sell | 2 k | 144,32 | 272 k USD |
| 2022-04-20 | SIMPSON TODD E | Chief Financial Officer | Sell | 567 | 144,32 | 82 k USD |
| 2022-04-20 | DANSEY ROGER D | Chief Medical Officer | Sell | 787 | 144,32 | 114 k USD |
| 2022-04-20 | HIMES VAUGHN B | Chief Technical Officer | Sell | 574 | 144,32 | 83 k USD |
| 2022-04-20 | ROMP CHARLES R | EVP, Commercial | Sell | 319 | 144,32 | 46 k USD |
| 2022-04-20 | LIU JEAN I | Chief Legal Officer | Sell | 401 | 144,32 | 58 k USD |
| 2022-04-20 | SIMPSON TODD E | Chief Financial Officer | Sell | 567 | 144,32 | 82 k USD |
| 2022-04-20 | SIEGALL CLAY B | President & CEO | Sell | 2 k | 144,32 | 272 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Buy | 2 k | 20,06 | 36 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Sell | 2 k | 143,32 | 257 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Buy | 2 k | 20,06 | 30 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Sell | 2 k | 144,17 | 219 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Buy | 690 | 20,06 | 14 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Sell | 690 | 145,08 | 100 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Buy | 2 k | 20,06 | 36 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Sell | 2 k | 143,32 | 257 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Buy | 2 k | 20,06 | 30 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Sell | 2 k | 144,17 | 219 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Buy | 690 | 20,06 | 14 k USD |
| 2022-04-19 | GRYSKA DAVID W | Director | Sell | 690 | 145,08 | 100 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 2 k | 26,10 | 43 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 2 k | 151,42 | 250 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 2 k | 26,10 | 55 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 2 k | 152,59 | 320 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 5 k | 26,10 | 122 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 5 k | 153,38 | 720 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 2 k | 26,10 | 63 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 2 k | 154,36 | 370 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 4 k | 26,10 | 100 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 4 k | 155,83 | 597 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 2 k | 26,10 | 50 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 2 k | 156,48 | 297 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 474 | 26,10 | 12 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 474 | 157,23 | 75 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 2 k | 26,10 | 43 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 2 k | 151,42 | 250 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 2 k | 26,10 | 55 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 2 k | 152,59 | 320 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 5 k | 26,10 | 122 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 5 k | 153,38 | 720 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 2 k | 26,10 | 63 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 2 k | 154,36 | 370 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 4 k | 26,10 | 100 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 4 k | 155,83 | 597 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 2 k | 26,10 | 50 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 2 k | 156,48 | 297 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Buy | 474 | 26,10 | 12 k USD |
| 2022-04-07 | SIEGALL CLAY B | President and CEO | Sell | 474 | 157,23 | 75 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-08 | BAKER BROS. ADVISORS LP | Director, 10% owner | Buy | 18 k | 20,06 | 351 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Buy | 100 | 26,10 | 3 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Sell | 100 | 136,33 | 14 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Buy | 4 k | 26,10 | 102 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Sell | 4 k | 132,72 | 518 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Buy | 2 k | 26,10 | 63 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Sell | 2 k | 133,69 | 321 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Buy | 7 k | 26,10 | 173 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Sell | 7 k | 134,74 | 895 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Buy | 4 k | 26,10 | 104 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Sell | 4 k | 135,62 | 542 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Buy | 100 | 26,10 | 3 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Sell | 100 | 136,33 | 14 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Buy | 4 k | 26,10 | 102 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Sell | 4 k | 132,72 | 518 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Buy | 2 k | 26,10 | 63 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Sell | 2 k | 133,69 | 321 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Buy | 7 k | 26,10 | 173 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Sell | 7 k | 134,74 | 895 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Buy | 4 k | 26,10 | 104 k USD |
| 2022-03-07 | SIEGALL CLAY B | President & CEO | Sell | 4 k | 135,62 | 542 k USD |
| 2022-03-03 | HIMES VAUGHN B | Chief Technical Officer | Buy | 11 k | 26,10 | 283 k USD |
| 2022-03-03 | HIMES VAUGHN B | Chief Technical Officer | Sell | 11 k | 126,98 | 1.4 mn USD |
| 2022-03-03 | HIMES VAUGHN B | Chief Technical Officer | Buy | 1 k | 26,10 | 30 k USD |
| 2022-03-03 | HIMES VAUGHN B | Chief Technical Officer | Sell | 1 k | 127,67 | 148 k USD |
| 2022-03-03 | HIMES VAUGHN B | Chief Technical Officer | Buy | 11 k | 26,10 | 283 k USD |
| 2022-03-03 | HIMES VAUGHN B | Chief Technical Officer | Sell | 11 k | 126,98 | 1.4 mn USD |
| 2022-03-03 | HIMES VAUGHN B | Chief Technical Officer | Buy | 1 k | 26,10 | 30 k USD |
| 2022-03-03 | HIMES VAUGHN B | Chief Technical Officer | Sell | 1 k | 127,67 | 148 k USD |
| 2022-03-02 | Simonian Nancy A | Director | Buy | 25 k | 20,04 | 501 k USD |
| 2022-03-02 | Simonian Nancy A | Director | Buy | 25 k | 20,04 | 501 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Buy | 1 k | 20,06 | 22 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Sell | 1 k | 137,45 | 151 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Buy | 1 k | 20,06 | 21 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Sell | 1 k | 138,66 | 143 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Buy | 2 k | 20,06 | 48 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Sell | 2 k | 139,42 | 331 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Buy | 100 | 26,10 | 3 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Sell | 100 | 137,29 | 14 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Buy | 4 k | 26,10 | 93 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Sell | 4 k | 138,97 | 497 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Buy | 9 k | 26,10 | 235 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Sell | 9 k | 139,96 | 1.3 mn USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Buy | 4 k | 26,10 | 107 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Sell | 4 k | 140,83 | 575 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Buy | 300 | 26,10 | 8 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Sell | 300 | 141,56 | 42 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Buy | 1 k | 20,06 | 22 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Sell | 1 k | 137,45 | 151 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Buy | 1 k | 20,06 | 21 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Sell | 1 k | 138,66 | 143 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Buy | 2 k | 20,06 | 48 k USD |
| 2022-02-07 | GRYSKA DAVID W | Director | Sell | 2 k | 139,42 | 331 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Buy | 100 | 26,10 | 3 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Sell | 100 | 137,29 | 14 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Buy | 4 k | 26,10 | 93 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Sell | 4 k | 138,97 | 497 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Buy | 9 k | 26,10 | 235 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Sell | 9 k | 139,96 | 1.3 mn USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Buy | 4 k | 26,10 | 107 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Sell | 4 k | 140,83 | 575 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Buy | 300 | 26,10 | 8 k USD |
| 2022-02-07 | SIEGALL CLAY B | President & CEO | Sell | 300 | 141,56 | 42 k USD |
| 2022-02-03 | DANSEY ROGER D | Chief Medical Officer | Sell | 703 | 136,14 | 96 k USD |
| 2022-02-03 | DANSEY ROGER D | Chief Medical Officer | Sell | 703 | 136,14 | 96 k USD |
| 2022-02-02 | DANSEY ROGER D | Chief Medical Officer | Sell | 739 | 137,58 | 102 k USD |
| 2022-02-02 | DANSEY ROGER D | Chief Medical Officer | Sell | 739 | 137,58 | 102 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Buy | 850 | 20,06 | 17 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Sell | 850 | 121,69 | 103 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Buy | 3 k | 20,06 | 51 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Sell | 3 k | 122,43 | 313 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Buy | 883 | 20,06 | 18 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Sell | 883 | 123,39 | 109 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Buy | 214 | 20,06 | 4 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Sell | 214 | 124,23 | 27 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Buy | 850 | 20,06 | 17 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Sell | 850 | 121,69 | 103 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Buy | 3 k | 20,06 | 51 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Sell | 3 k | 122,43 | 313 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Buy | 883 | 20,06 | 18 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Sell | 883 | 123,39 | 109 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Buy | 214 | 20,06 | 4 k USD |
| 2022-01-28 | GRYSKA DAVID W | Director | Sell | 214 | 124,23 | 27 k USD |
| 2022-01-18 | LIU JEAN I | Chief Legal Officer | Buy | 6 k | 0,00 | 0 USD |
| 2022-01-18 | LIU JEAN I | Chief Legal Officer | Buy | 6 k | 0,00 | 0 USD |
| 2022-01-14 | GRYSKA DAVID W | Director | Buy | 5 k | 20,06 | 90 k USD |
| 2022-01-14 | GRYSKA DAVID W | Director | Sell | 5 k | 135,24 | 609 k USD |
| 2022-01-14 | GRYSKA DAVID W | Director | Buy | 5 k | 20,06 | 90 k USD |
| 2022-01-14 | GRYSKA DAVID W | Director | Sell | 5 k | 135,24 | 609 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Buy | 1 k | 26,10 | 29 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Sell | 1 k | 147,16 | 162 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Buy | 3 k | 26,10 | 84 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Sell | 3 k | 145,84 | 470 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Buy | 5 k | 26,10 | 119 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Sell | 5 k | 144,82 | 660 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Buy | 8 k | 26,10 | 213 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Sell | 8 k | 143,91 | 1.2 mn USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Buy | 1 k | 26,10 | 29 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Sell | 1 k | 147,16 | 162 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Buy | 3 k | 26,10 | 84 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Sell | 3 k | 145,84 | 470 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Buy | 5 k | 26,10 | 119 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Sell | 5 k | 144,82 | 660 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Buy | 8 k | 26,10 | 213 k USD |
| 2022-01-07 | SIEGALL CLAY B | President & CEO | Sell | 8 k | 143,91 | 1.2 mn USD |
| 2022-01-03 | DANSEY ROGER D | Chief Medical Officer | Sell | 3 k | 152,58 | 529 k USD |
| 2022-01-03 | DANSEY ROGER D | Chief Medical Officer | Sell | 3 k | 152,58 | 529 k USD |
| 2022-01-03 | DANSEY ROGER D | Chief Medical Officer | Sell | 2 k | 152,58 | 265 k USD |
| 2022-01-03 | DANSEY ROGER D | Chief Medical Officer | Sell | 3 k | 152,58 | 529 k USD |
| 2022-01-03 | DANSEY ROGER D | Chief Medical Officer | Sell | 3 k | 152,58 | 529 k USD |
| 2022-01-03 | DANSEY ROGER D | Chief Medical Officer | Sell | 2 k | 152,58 | 265 k USD |
| 2021-12-21 | DANSEY ROGER D | Chief Medical Officer | Sell | 280 | 155,58 | 44 k USD |
| 2021-12-21 | DANSEY ROGER D | Chief Medical Officer | Sell | 280 | 155,58 | 44 k USD |
| 2021-12-20 | DANSEY ROGER D | Chief Medical Officer | Sell | 280 | 149,85 | 42 k USD |
| 2021-12-20 | HIMES VAUGHN B | Chief Technical Officer | Sell | 345 | 149,85 | 52 k USD |
| 2021-12-20 | LIU JEAN I | Chief Legal Officer | Sell | 276 | 149,85 | 41 k USD |
| 2021-12-20 | ROMP CHARLES R | EVP, Commercial | Sell | 194 | 149,85 | 29 k USD |
| 2021-12-20 | ROMP CHARLES R | EVP, Commercial | Sell | 1 k | 149,85 | 169 k USD |
| 2021-12-20 | SIEGALL CLAY B | President & CEO | Sell | 1 k | 149,85 | 184 k USD |
| 2021-12-20 | SIMPSON TODD E | Chief Financial Officer | Sell | 345 | 149,85 | 52 k USD |
| 2021-12-20 | LIU JEAN I | Chief Legal Officer | Sell | 276 | 149,85 | 41 k USD |
| 2021-12-20 | SIMPSON TODD E | Chief Financial Officer | Sell | 345 | 149,85 | 52 k USD |
| 2021-12-20 | SIEGALL CLAY B | President & CEO | Sell | 1 k | 149,85 | 184 k USD |
| 2021-12-20 | DANSEY ROGER D | Chief Medical Officer | Sell | 280 | 149,85 | 42 k USD |
| 2021-12-20 | HIMES VAUGHN B | Chief Technical Officer | Sell | 345 | 149,85 | 52 k USD |
| 2021-12-20 | ROMP CHARLES R | EVP, Commercial | Sell | 194 | 149,85 | 29 k USD |
| 2021-12-20 | ROMP CHARLES R | EVP, Commercial | Sell | 1 k | 149,85 | 169 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Buy | 2 k | 26,10 | 43 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Sell | 2 k | 146,54 | 242 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Buy | 12 k | 26,10 | 319 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Sell | 12 k | 147,83 | 1.8 mn USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Buy | 15 k | 26,10 | 383 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Sell | 15 k | 148,27 | 2.2 mn USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Buy | 12 k | 26,10 | 301 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Sell | 12 k | 149,56 | 1.7 mn USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Buy | 5 k | 26,10 | 140 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Sell | 5 k | 150,38 | 804 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Buy | 2 k | 26,10 | 43 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Sell | 2 k | 146,54 | 242 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Buy | 12 k | 26,10 | 319 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Sell | 12 k | 147,83 | 1.8 mn USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Buy | 15 k | 26,10 | 383 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Sell | 15 k | 148,27 | 2.2 mn USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Buy | 12 k | 26,10 | 301 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Sell | 12 k | 149,56 | 1.7 mn USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Buy | 5 k | 26,10 | 140 k USD |
| 2021-12-07 | SIEGALL CLAY B | President & CEO | Sell | 5 k | 150,38 | 804 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,80 | 383 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 26 k | 160,80 | 4.2 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 768 | 161,35 | 124 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 8 k | 161,35 | 1.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 5 k | 161,39 | 765 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 51 k | 161,39 | 8.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,80 | 383 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 26 k | 160,80 | 4.2 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 768 | 161,35 | 124 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 8 k | 161,35 | 1.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 5 k | 161,39 | 765 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 51 k | 161,39 | 8.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,80 | 383 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 26 k | 160,80 | 4.2 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 768 | 161,35 | 124 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 8 k | 161,35 | 1.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 5 k | 161,39 | 765 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 51 k | 161,39 | 8.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,80 | 383 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 26 k | 160,80 | 4.2 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 768 | 161,35 | 124 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 8 k | 161,35 | 1.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 5 k | 161,39 | 765 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 51 k | 161,39 | 8.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,80 | 383 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 26 k | 160,80 | 4.2 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 768 | 161,35 | 124 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 8 k | 161,35 | 1.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 5 k | 161,39 | 765 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 51 k | 161,39 | 8.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,80 | 383 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 26 k | 160,80 | 4.2 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 768 | 161,35 | 124 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 8 k | 161,35 | 1.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 5 k | 161,39 | 765 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 51 k | 161,39 | 8.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,80 | 383 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 26 k | 160,80 | 4.2 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 768 | 161,35 | 124 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 8 k | 161,35 | 1.3 mn USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 5 k | 161,39 | 765 k USD |
| 2021-12-01 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 51 k | 161,39 | 8.3 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 19 k | 160,00 | 3.1 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 160,00 | 33.4 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 540 | 160,08 | 86 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 6 k | 160,08 | 938 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 3 k | 160,53 | 436 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 29 k | 160,53 | 4.7 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,96 | 299 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 20 k | 160,96 | 3.2 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 123 | 163,39 | 20 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 163,39 | 218 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 886 | 164,82 | 146 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 10 k | 164,82 | 1.6 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 93 | 165,68 | 15 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 165,68 | 167 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 19 k | 160,00 | 3.1 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 160,00 | 33.4 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 540 | 160,08 | 86 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 6 k | 160,08 | 938 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 3 k | 160,53 | 436 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 29 k | 160,53 | 4.7 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,96 | 299 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 20 k | 160,96 | 3.2 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 123 | 163,39 | 20 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 163,39 | 218 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 886 | 164,82 | 146 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 10 k | 164,82 | 1.6 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 93 | 165,68 | 15 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 165,68 | 167 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 19 k | 160,00 | 3.1 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 160,00 | 33.4 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 540 | 160,08 | 86 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 6 k | 160,08 | 938 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 3 k | 160,53 | 436 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 29 k | 160,53 | 4.7 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,96 | 299 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 20 k | 160,96 | 3.2 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 123 | 163,39 | 20 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 163,39 | 218 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 886 | 164,82 | 146 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 10 k | 164,82 | 1.6 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 93 | 165,68 | 15 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 165,68 | 167 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 19 k | 160,00 | 3.1 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 160,00 | 33.4 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 540 | 160,08 | 86 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 6 k | 160,08 | 938 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 3 k | 160,53 | 436 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 29 k | 160,53 | 4.7 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,96 | 299 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 20 k | 160,96 | 3.2 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 123 | 163,39 | 20 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 163,39 | 218 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 886 | 164,82 | 146 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 10 k | 164,82 | 1.6 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 93 | 165,68 | 15 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 165,68 | 167 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 19 k | 160,00 | 3.1 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 160,00 | 33.4 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 540 | 160,08 | 86 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 6 k | 160,08 | 938 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 3 k | 160,53 | 436 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 29 k | 160,53 | 4.7 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,96 | 299 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 20 k | 160,96 | 3.2 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 123 | 163,39 | 20 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 163,39 | 218 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 886 | 164,82 | 146 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 10 k | 164,82 | 1.6 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 93 | 165,68 | 15 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 165,68 | 167 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 19 k | 160,00 | 3.1 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 160,00 | 33.4 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 540 | 160,08 | 86 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 6 k | 160,08 | 938 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 3 k | 160,53 | 436 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 29 k | 160,53 | 4.7 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,96 | 299 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 20 k | 160,96 | 3.2 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 123 | 163,39 | 20 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 163,39 | 218 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 886 | 164,82 | 146 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 10 k | 164,82 | 1.6 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 93 | 165,68 | 15 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 165,68 | 167 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 19 k | 160,00 | 3.1 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 209 k | 160,00 | 33.4 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 540 | 160,08 | 86 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 6 k | 160,08 | 938 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 3 k | 160,53 | 436 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 29 k | 160,53 | 4.7 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 2 k | 160,96 | 299 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 20 k | 160,96 | 3.2 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 123 | 163,39 | 20 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 163,39 | 218 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 886 | 164,82 | 146 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 10 k | 164,82 | 1.6 mn USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 93 | 165,68 | 15 k USD |
| 2021-11-30 | BAKER BROS. ADVISORS LP | Director, 10% owner | Sell | 1 k | 165,68 | 167 k USD |
| 2021-11-11 | HIMES VAUGHN B | Chief Technical Officer | Buy | 6 k | 26,10 | 157 k USD |
| 2021-11-11 | HIMES VAUGHN B | Chief Technical Officer | Sell | 2 k | 177,94 | 359 k USD |
| 2021-11-11 | HIMES VAUGHN B | Chief Technical Officer | Sell | 3 k | 178,82 | 602 k USD |
| 2021-11-11 | HIMES VAUGHN B | Chief Technical Officer | Sell | 617 | 179,84 | 111 k USD |
| 2021-11-11 | HIMES VAUGHN B | Chief Technical Officer | Buy | 6 k | 26,10 | 157 k USD |